Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Cidade, M. T.
Data de Publicação: 2019
Outros Autores: Ramos, D. J., Santos, J., Carrelo, H., Calero, N., Borges, J. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/146318
Resumo: The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.
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spelling Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applicationsAlginate microparticlesCompositesDual cargo delivery systemsInjectable gelsPluronic/water systemsRheologyMaterials Science(all)The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNCidade, M. T.Ramos, D. J.Santos, J.Carrelo, H.Calero, N.Borges, J. P.2022-12-16T22:07:35Z2019-04-022019-04-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/146318eng1996-1944PURE: 13457635https://doi.org/10.3390/ma12071083info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:27:24Zoai:run.unl.pt:10362/146318Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:35.234853Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
title Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
spellingShingle Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
Cidade, M. T.
Alginate microparticles
Composites
Dual cargo delivery systems
Injectable gels
Pluronic/water systems
Rheology
Materials Science(all)
title_short Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
title_full Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
title_fullStr Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
title_full_unstemmed Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
title_sort Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
author Cidade, M. T.
author_facet Cidade, M. T.
Ramos, D. J.
Santos, J.
Carrelo, H.
Calero, N.
Borges, J. P.
author_role author
author2 Ramos, D. J.
Santos, J.
Carrelo, H.
Calero, N.
Borges, J. P.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Cidade, M. T.
Ramos, D. J.
Santos, J.
Carrelo, H.
Calero, N.
Borges, J. P.
dc.subject.por.fl_str_mv Alginate microparticles
Composites
Dual cargo delivery systems
Injectable gels
Pluronic/water systems
Rheology
Materials Science(all)
topic Alginate microparticles
Composites
Dual cargo delivery systems
Injectable gels
Pluronic/water systems
Rheology
Materials Science(all)
description The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-02
2019-04-02T00:00:00Z
2022-12-16T22:07:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/146318
url http://hdl.handle.net/10362/146318
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1996-1944
PURE: 13457635
https://doi.org/10.3390/ma12071083
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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