Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
Autor(a) principal: | |
---|---|
Data de Publicação: | 1999 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/17891 |
Resumo: | © 1999 – IOS Press. All rights reserved |
id |
RCAP_3f70b397835fe5112116295e42e5dd88 |
---|---|
oai_identifier_str |
oai:repositorio.ul.pt:10451/17891 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective© 1999 – IOS Press. All rights reservedPrevious studies have documented structural and functional changes induced by ethanol–erythrocyte membrane interaction. In order to perform an in vitro study on the effect of different ethanol concentrations on erythrocyte hemorheologic properties, blood samples were collected from 21 male donors at the Hospital of Santa Maria. Whole blood aliquots were incubated with ethanol solutions of rising concentrations. The following parameters were measured: erythrocyte aggregation, haemoglobin, carboxyhaemoglobin and methaemoglobin concentrations, hematocrit, plasma osmolality and erythrocyte membrane fluidity (fluorescence polarisation probes TMA-DPH and DPH). With ethanol blood concentrations of 45 mM a rise in plasma osmolality (0.352 Osm/kg H2O vs 0.310 Osm/kg H2O; p < 0.001) was verified. With 67 mM concentration a decrease of erythrocyte aggregation (11.03 vs 12.81; p < 0.05) and an increase in plasma osmolality (0.380 Osm/kg H2O vs 0.310 Osm/kg H2O;p < 0.001) were obtained. In conclusion, ethanol only changes erythrocyte aggregation for a concentration of 67 mM. These data could lead to future changes in therapeutic approaches to situations such as alcoholic coma.IOS PressRepositório da Universidade de LisboaMesquita, R.Gonçalves, M. I.Dias, S.Sargento, L.Saldanha, C.Martins e Silva, J.2015-04-14T10:26:47Z19991999-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17891engClinical Hemorheology and Microcirculation 21 (1999) 95–981386-0291http://iospress.metapress.com/content/455nmpjftq4ybkj7/?p=4d7a0fdd1d23412eabfc243594816b78&pi=2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:47Zoai:repositorio.ul.pt:10451/17891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:36.689269Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
title |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
spellingShingle |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective Mesquita, R. |
title_short |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
title_full |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
title_fullStr |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
title_full_unstemmed |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
title_sort |
Ethanol and erythrocyte membrane interaction : a hemorheologic perspective |
author |
Mesquita, R. |
author_facet |
Mesquita, R. Gonçalves, M. I. Dias, S. Sargento, L. Saldanha, C. Martins e Silva, J. |
author_role |
author |
author2 |
Gonçalves, M. I. Dias, S. Sargento, L. Saldanha, C. Martins e Silva, J. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Mesquita, R. Gonçalves, M. I. Dias, S. Sargento, L. Saldanha, C. Martins e Silva, J. |
description |
© 1999 – IOS Press. All rights reserved |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999 1999-01-01T00:00:00Z 2015-04-14T10:26:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/17891 |
url |
http://hdl.handle.net/10451/17891 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Hemorheology and Microcirculation 21 (1999) 95–98 1386-0291 http://iospress.metapress.com/content/455nmpjftq4ybkj7/?p=4d7a0fdd1d23412eabfc243594816b78&pi=2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IOS Press |
publisher.none.fl_str_mv |
IOS Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134273895137280 |