Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges

Detalhes bibliográficos
Autor(a) principal: Santos, Marina I.
Data de Publicação: 2010
Outros Autores: Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/20647
Resumo: The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network.
id RCAP_441062f04b5c14dda763907c167cf085
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/20647
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challengesbiomaterialsbonefracture repairtissue engineeringvascularizationScience & TechnologyThe lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network.M. I. Santos would like to acknowledge the Portuguese Foundation for Science and Technology (FCT) for her Ph.D. grant (SFRH/BD/13428/2003). This work was partially supported by FCT through funds from POCTI and/or FEDER programs and by the European Union funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283). The authors also acknowledge Gabriela A. Silva for critically reading the manuscript.WileyUniversidade do MinhoSantos, Marina I.Reis, R. L.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20647eng1616-518710.1002/mabi.20090010719688722info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:07Zoai:repositorium.sdum.uminho.pt:1822/20647Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:44:38.478648Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
title Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
spellingShingle Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
Santos, Marina I.
biomaterials
bone
fracture repair
tissue engineering
vascularization
Science & Technology
title_short Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
title_full Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
title_fullStr Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
title_full_unstemmed Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
title_sort Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges
author Santos, Marina I.
author_facet Santos, Marina I.
Reis, R. L.
author_role author
author2 Reis, R. L.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, Marina I.
Reis, R. L.
dc.subject.por.fl_str_mv biomaterials
bone
fracture repair
tissue engineering
vascularization
Science & Technology
topic biomaterials
bone
fracture repair
tissue engineering
vascularization
Science & Technology
description The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/20647
url http://hdl.handle.net/1822/20647
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1616-5187
10.1002/mabi.200900107
19688722
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132196371431424

Registros relacionados