Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation

Detalhes bibliográficos
Autor(a) principal: Lopes, Soraia V.
Data de Publicação: 2021
Outros Autores: Collins, Maurice N., Reis, R. L., Oliveira, J. M., Silva-Correia, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/71989
Resumo: This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
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spelling Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulationAngiogenesisIn vitro/in vivo assaysTissue engineeringTissue scaffoldsVascularizationScience & TechnologyThis review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.The authors acknowledge the financial support provided through the projects B-FABULUS (PTDC/BBB-ECT/2690/2014) and Fun4TE (PTDC/EMD-EMD/31367/2017), financed by the Portuguese Foundation for Science and Technology (FCT) and cofinanced by European Regional Development Fund (FEDER) and Operational Programme for Competitiveness and Internationalisation (POCI). This work was also partly supported by H2020-MSCA-RISE BAMOS project, funded from the European Union's Horizon 2020 research and innovation program under Grant Agreement No. 734156. S.V.L. acknowledges FCT for the PhD grant (SFRH/BD/143954/2019). The FCT distinction attributed to J.S.-C. (IF/00115/2015) under the Investigator FCT program is also greatly acknowledged.American Chemical SocietyUniversidade do MinhoLopes, Soraia V.Collins, Maurice N.Reis, R. L.Oliveira, J. M.Silva-Correia, Joana2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/71989engLopes S. V., Collins M. N., Reis R. L., Oliveira J. M., Silva-Correia J. Vascularization Approaches in Tissue Engineering: Recent Developments on Evaluation Tests and Modulation, ACS Applied Bio Materials, doi:10.1021/acsabm.1c00051, 20212576-642210.1021/acsabm.1c0005135014385https://doi.org/10.1021/acsabm.1c00051info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:49Zoai:repositorium.sdum.uminho.pt:1822/71989Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:26:04.373086Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
title Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
spellingShingle Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
Lopes, Soraia V.
Angiogenesis
In vitro/in vivo assays
Tissue engineering
Tissue scaffolds
Vascularization
Science & Technology
title_short Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
title_full Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
title_fullStr Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
title_full_unstemmed Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
title_sort Vascularization approaches in tissue engineering: recent developments on evaluation tests and modulation
author Lopes, Soraia V.
author_facet Lopes, Soraia V.
Collins, Maurice N.
Reis, R. L.
Oliveira, J. M.
Silva-Correia, Joana
author_role author
author2 Collins, Maurice N.
Reis, R. L.
Oliveira, J. M.
Silva-Correia, Joana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Lopes, Soraia V.
Collins, Maurice N.
Reis, R. L.
Oliveira, J. M.
Silva-Correia, Joana
dc.subject.por.fl_str_mv Angiogenesis
In vitro/in vivo assays
Tissue engineering
Tissue scaffolds
Vascularization
Science & Technology
topic Angiogenesis
In vitro/in vivo assays
Tissue engineering
Tissue scaffolds
Vascularization
Science & Technology
description This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
2021-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/71989
url https://hdl.handle.net/1822/71989
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lopes S. V., Collins M. N., Reis R. L., Oliveira J. M., Silva-Correia J. Vascularization Approaches in Tissue Engineering: Recent Developments on Evaluation Tests and Modulation, ACS Applied Bio Materials, doi:10.1021/acsabm.1c00051, 2021
2576-6422
10.1021/acsabm.1c00051
35014385
https://doi.org/10.1021/acsabm.1c00051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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