Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy

Detalhes bibliográficos
Autor(a) principal: Riera-Domingo, Carla
Data de Publicação: 2020
Outros Autores: Audigé, Annette, Granja, Sara Costa, Cheng, Wan-Chen, Ho, Ping-Chih, Baltazar, Fátima, Stockmann, Christian, Mazzone, Massimiliano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62516
Resumo: It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.
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spelling Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for ImmunotherapycancerhypoxiaimmunometabolismimmunotherapymetabolismCiências Médicas::Medicina BásicaScience & TechnologyIt is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.M. Mazzone was supported by European Research Council (ERC) Consolidator Grant 773208, Fonds Wetenschappelijk Onderzoek (Flemish Research Foundation) Grants G0D1717N and G066515N, and Stichting Tegen Kanker (Fondation Contre le Cancer) Grant 2014197. C. Riera-Domingo was supported by Fonds Wetenschappelijk Onderzoek (Flemish Research Foundation) Grant 1108919N. S. Granja received a fellowship from the Foundation for Science and Technology (FCT) Ref. No. SFRH/BPD/117858/2016. F. Baltazar worked under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020) under the Portugal Partnership Agreement, through the European Regional Development Fund (FEDER), and through the Competitiveness Factors Operational Programme (COMPETE) and by National funds, through the FCT, under the scope of the project POCI-01-0145-FEDER-007038. F. Baltazar also acknowledges financial support from the projects Ref. No. NORTE-01-0145-FEDER-031142 and UTAP-EXPL/NTec/0038/2017. C. Stockmann was supported by Swiss National Fund (179235), the Swiss Cancer Research (KFS-4397-02-2018), and the National Center of Compentence in Research (NCCR): Kidney Control of Homeostasis (183774). P.-C. Ho was supported in part by the SNSF Project Grant 31003A_182470 and ERC Staring Grant 802773-Mito-Guide.American Physiological SocietyUniversidade do MinhoRiera-Domingo, CarlaAudigé, AnnetteGranja, Sara CostaCheng, Wan-ChenHo, Ping-ChihBaltazar, FátimaStockmann, ChristianMazzone, Massimiliano20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62516engRiera-Domingo, C., Audigé, A., et. al.(2019). Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy. Physiological reviews, 100(1), 1-102.0031-93331522-121010.1152/physrev.00018.201931414610https://www.physiology.org/doi/abs/10.1152/physrev.00018.2019info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:57Zoai:repositorium.sdum.uminho.pt:1822/62516Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:11:48.863965Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
title Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
spellingShingle Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, Carla
cancer
hypoxia
immunometabolism
immunotherapy
metabolism
Ciências Médicas::Medicina Básica
Science & Technology
title_short Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
title_full Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
title_fullStr Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
title_full_unstemmed Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
title_sort Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
author Riera-Domingo, Carla
author_facet Riera-Domingo, Carla
Audigé, Annette
Granja, Sara Costa
Cheng, Wan-Chen
Ho, Ping-Chih
Baltazar, Fátima
Stockmann, Christian
Mazzone, Massimiliano
author_role author
author2 Audigé, Annette
Granja, Sara Costa
Cheng, Wan-Chen
Ho, Ping-Chih
Baltazar, Fátima
Stockmann, Christian
Mazzone, Massimiliano
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Riera-Domingo, Carla
Audigé, Annette
Granja, Sara Costa
Cheng, Wan-Chen
Ho, Ping-Chih
Baltazar, Fátima
Stockmann, Christian
Mazzone, Massimiliano
dc.subject.por.fl_str_mv cancer
hypoxia
immunometabolism
immunotherapy
metabolism
Ciências Médicas::Medicina Básica
Science & Technology
topic cancer
hypoxia
immunometabolism
immunotherapy
metabolism
Ciências Médicas::Medicina Básica
Science & Technology
description It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62516
url http://hdl.handle.net/1822/62516
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Riera-Domingo, C., Audigé, A., et. al.(2019). Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy. Physiological reviews, 100(1), 1-102.
0031-9333
1522-1210
10.1152/physrev.00018.2019
31414610
https://www.physiology.org/doi/abs/10.1152/physrev.00018.2019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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