Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103767 https://doi.org/10.3390/biom11060770 |
Resumo: | Microglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglial cell reactivity occurs in an orchestrated manner and propagates across the neural parenchyma spreading the neuroinflammatory signal from cell to cell. Extracellular vesicles are important vehicles of intercellular communication and act as message carriers across boundaries. Extracellular vesicles can be subdivided in several categories according to their cellular origin (apoptotic bodies, microvesicles and exosomes), each presenting, different but sometimes overlapping functions in cell communication. Mounting evidence suggests a role for extracellular vesicles in regulating microglial cell action. Herein, we explore the role of microglial extracellular vesicles as vehicles for cell communication and the mechanisms that trigger their release. In this review we covered the role of microglial extracellular vesicles, focusing on apoptotic bodies, microvesicles and exosomes, in the context of neurodegeneration and the impact of these vesicles derived from other cells in microglial cell reactivity. |
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Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreadingexosomesextracellular vesiclesmicrogliamicrovesiclesneurodegenerationMicroglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglial cell reactivity occurs in an orchestrated manner and propagates across the neural parenchyma spreading the neuroinflammatory signal from cell to cell. Extracellular vesicles are important vehicles of intercellular communication and act as message carriers across boundaries. Extracellular vesicles can be subdivided in several categories according to their cellular origin (apoptotic bodies, microvesicles and exosomes), each presenting, different but sometimes overlapping functions in cell communication. Mounting evidence suggests a role for extracellular vesicles in regulating microglial cell action. Herein, we explore the role of microglial extracellular vesicles as vehicles for cell communication and the mechanisms that trigger their release. In this review we covered the role of microglial extracellular vesicles, focusing on apoptotic bodies, microvesicles and exosomes, in the context of neurodegeneration and the impact of these vesicles derived from other cells in microglial cell reactivity.This research was funded by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/01/2020); PhD fellowships PD/BD/52294/2013, PD/BD/114115/2015 and PD/BD/127821/2016), COMPETE-FEDER (FCOMP-01-0124-FEDER-028417; and POCI-01-0145-FEDER-007440), Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020; CENTRO-01-0145- FEDER-000012-N2323: HealthyAging2020), Banco Santander Totta (grant FMUC-BST-2016-224).MDPI AG2021-05-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103767http://hdl.handle.net/10316/103767https://doi.org/10.3390/biom11060770eng2218-273X340638322218-273XAires, Inês DinisRibeiro-Rodrigues, TeresaBoia, Raquel Sofia FreitasFerreira-Rodrigues, MagdaGirão, HenriqueAmbrósio, António FranciscoSantiago, Ana Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:17Zoai:estudogeral.uc.pt:10316/103767Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:32.817103Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
title |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
spellingShingle |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading Aires, Inês Dinis exosomes extracellular vesicles microglia microvesicles neurodegeneration |
title_short |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
title_full |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
title_fullStr |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
title_full_unstemmed |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
title_sort |
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading |
author |
Aires, Inês Dinis |
author_facet |
Aires, Inês Dinis Ribeiro-Rodrigues, Teresa Boia, Raquel Sofia Freitas Ferreira-Rodrigues, Magda Girão, Henrique Ambrósio, António Francisco Santiago, Ana Raquel |
author_role |
author |
author2 |
Ribeiro-Rodrigues, Teresa Boia, Raquel Sofia Freitas Ferreira-Rodrigues, Magda Girão, Henrique Ambrósio, António Francisco Santiago, Ana Raquel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Aires, Inês Dinis Ribeiro-Rodrigues, Teresa Boia, Raquel Sofia Freitas Ferreira-Rodrigues, Magda Girão, Henrique Ambrósio, António Francisco Santiago, Ana Raquel |
dc.subject.por.fl_str_mv |
exosomes extracellular vesicles microglia microvesicles neurodegeneration |
topic |
exosomes extracellular vesicles microglia microvesicles neurodegeneration |
description |
Microglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglial cell reactivity occurs in an orchestrated manner and propagates across the neural parenchyma spreading the neuroinflammatory signal from cell to cell. Extracellular vesicles are important vehicles of intercellular communication and act as message carriers across boundaries. Extracellular vesicles can be subdivided in several categories according to their cellular origin (apoptotic bodies, microvesicles and exosomes), each presenting, different but sometimes overlapping functions in cell communication. Mounting evidence suggests a role for extracellular vesicles in regulating microglial cell action. Herein, we explore the role of microglial extracellular vesicles as vehicles for cell communication and the mechanisms that trigger their release. In this review we covered the role of microglial extracellular vesicles, focusing on apoptotic bodies, microvesicles and exosomes, in the context of neurodegeneration and the impact of these vesicles derived from other cells in microglial cell reactivity. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103767 http://hdl.handle.net/10316/103767 https://doi.org/10.3390/biom11060770 |
url |
http://hdl.handle.net/10316/103767 https://doi.org/10.3390/biom11060770 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2218-273X 34063832 2218-273X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134097814061056 |