Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/125087 |
Resumo: | Funding Information: We acknowledge support from the NOVA Medical School of Universidade NOVA de Lisboa, CINTESIS, and CHRC. Funding. This study was sponsored by the Funda??o para a Ci?ncia e a Tecnologia (FCT, project no. 268_596883842), BIOCODEX, and CINTESIS (reference UIDB/4255/2020). The funders had no role in study design, data collection, data analysis, data interpretation, or manuscript writing. Publisher Copyright: © Copyright © 2021 Moreira-Rosário, Marques, Pinheiro, Araújo, Ribeiro, Rocha, Mota, Pestana, Ribeiro, Pereira, de Sousa, Pereira-Leal, de Sousa, Morais, Teixeira, Rocha, Silvestre, Príncipe, Gatta, Amado, Santos, Maltez, Boquinhas, de Sousa, Germano, Sarmento, Granja, Póvoa, Faria and Calhau. |
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Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 PatientsCOVID-19dysbiosisgut microbiotaShannon—Weiner diversity indexWHO Clinical Progression ScaleMicrobiologyMicrobiology (medical)Funding Information: We acknowledge support from the NOVA Medical School of Universidade NOVA de Lisboa, CINTESIS, and CHRC. Funding. This study was sponsored by the Funda??o para a Ci?ncia e a Tecnologia (FCT, project no. 268_596883842), BIOCODEX, and CINTESIS (reference UIDB/4255/2020). The funders had no role in study design, data collection, data analysis, data interpretation, or manuscript writing. Publisher Copyright: © Copyright © 2021 Moreira-Rosário, Marques, Pinheiro, Araújo, Ribeiro, Rocha, Mota, Pestana, Ribeiro, Pereira, de Sousa, Pereira-Leal, de Sousa, Morais, Teixeira, Rocha, Silvestre, Príncipe, Gatta, Amado, Santos, Maltez, Boquinhas, de Sousa, Germano, Sarmento, Granja, Póvoa, Faria and Calhau.The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity.Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNMoreira-Rosário, AndréMarques, CláudiaPinheiro, HélderAraújo, João RicardoRibeiro, PedroRocha, RitaMota, InêsPestana, DiogoRibeiro, RitaPereira, Anade Sousa, Maria JoséPereira-Leal, Joséde Sousa, JoséMorais, JulianaTeixeira, DianaRocha, Júlio CésarSilvestre, MartaPríncipe, NunoGatta, NunoAmado, JoséSantos, LurdesMaltez, FernandoBoquinhas, Anade Sousa, GermanoGermano, NunoSarmento, GonçaloGranja, CristinaPovoa, PedroFaria, AnaCalhau, Conceição2021-09-24T02:24:50Z2021-07-192021-07-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/125087eng1664-302XPURE: 33429110https://doi.org/10.3389/fmicb.2021.705020info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:16Zoai:run.unl.pt:10362/125087Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:39.311816Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| title |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| spellingShingle |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients Moreira-Rosário, André COVID-19 dysbiosis gut microbiota Shannon—Weiner diversity index WHO Clinical Progression Scale Microbiology Microbiology (medical) |
| title_short |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| title_full |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| title_fullStr |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| title_full_unstemmed |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| title_sort |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
| author |
Moreira-Rosário, André |
| author_facet |
Moreira-Rosário, André Marques, Cláudia Pinheiro, Hélder Araújo, João Ricardo Ribeiro, Pedro Rocha, Rita Mota, Inês Pestana, Diogo Ribeiro, Rita Pereira, Ana de Sousa, Maria José Pereira-Leal, José de Sousa, José Morais, Juliana Teixeira, Diana Rocha, Júlio César Silvestre, Marta Príncipe, Nuno Gatta, Nuno Amado, José Santos, Lurdes Maltez, Fernando Boquinhas, Ana de Sousa, Germano Germano, Nuno Sarmento, Gonçalo Granja, Cristina Povoa, Pedro Faria, Ana Calhau, Conceição |
| author_role |
author |
| author2 |
Marques, Cláudia Pinheiro, Hélder Araújo, João Ricardo Ribeiro, Pedro Rocha, Rita Mota, Inês Pestana, Diogo Ribeiro, Rita Pereira, Ana de Sousa, Maria José Pereira-Leal, José de Sousa, José Morais, Juliana Teixeira, Diana Rocha, Júlio César Silvestre, Marta Príncipe, Nuno Gatta, Nuno Amado, José Santos, Lurdes Maltez, Fernando Boquinhas, Ana de Sousa, Germano Germano, Nuno Sarmento, Gonçalo Granja, Cristina Povoa, Pedro Faria, Ana Calhau, Conceição |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Moreira-Rosário, André Marques, Cláudia Pinheiro, Hélder Araújo, João Ricardo Ribeiro, Pedro Rocha, Rita Mota, Inês Pestana, Diogo Ribeiro, Rita Pereira, Ana de Sousa, Maria José Pereira-Leal, José de Sousa, José Morais, Juliana Teixeira, Diana Rocha, Júlio César Silvestre, Marta Príncipe, Nuno Gatta, Nuno Amado, José Santos, Lurdes Maltez, Fernando Boquinhas, Ana de Sousa, Germano Germano, Nuno Sarmento, Gonçalo Granja, Cristina Povoa, Pedro Faria, Ana Calhau, Conceição |
| dc.subject.por.fl_str_mv |
COVID-19 dysbiosis gut microbiota Shannon—Weiner diversity index WHO Clinical Progression Scale Microbiology Microbiology (medical) |
| topic |
COVID-19 dysbiosis gut microbiota Shannon—Weiner diversity index WHO Clinical Progression Scale Microbiology Microbiology (medical) |
| description |
Funding Information: We acknowledge support from the NOVA Medical School of Universidade NOVA de Lisboa, CINTESIS, and CHRC. Funding. This study was sponsored by the Funda??o para a Ci?ncia e a Tecnologia (FCT, project no. 268_596883842), BIOCODEX, and CINTESIS (reference UIDB/4255/2020). The funders had no role in study design, data collection, data analysis, data interpretation, or manuscript writing. Publisher Copyright: © Copyright © 2021 Moreira-Rosário, Marques, Pinheiro, Araújo, Ribeiro, Rocha, Mota, Pestana, Ribeiro, Pereira, de Sousa, Pereira-Leal, de Sousa, Morais, Teixeira, Rocha, Silvestre, Príncipe, Gatta, Amado, Santos, Maltez, Boquinhas, de Sousa, Germano, Sarmento, Granja, Póvoa, Faria and Calhau. |
| publishDate |
2021 |
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2021-09-24T02:24:50Z 2021-07-19 2021-07-19T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/125087 |
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http://hdl.handle.net/10362/125087 |
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eng |
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eng |
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1664-302X PURE: 33429110 https://doi.org/10.3389/fmicb.2021.705020 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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