Rational design of affinity ligands for bioseparation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/141849 |
Resumo: | Fundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM. |
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Rational design of affinity ligands for bioseparationAffinity ligandsBioseparationDownstream processingMolecular recognitionRational designAnalytical ChemistryBiochemistryOrganic ChemistryFundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM.Affinity adsorbents have been the cornerstone in protein purification. The selective nature of the molecular recognition interactions established between an affinity ligands and its target provide the basis for efficient capture and isolation of proteins. The plethora of affinity adsorbents available in the market reflects the importance of affinity chromatography in the bioseparation industry. Ligand discovery relies on the implementation of rational design techniques, which provides the foundation for the engineering of novel affinity ligands. The main goal for the design of affinity ligands is to discover or improve functionality, such as increased stability or selectivity. However, the methodologies must adapt to the current needs, namely to the number and diversity of biologicals being developed, and the availability of new tools for big data analysis and artificial intelligence. In this review, we offer an overview on the development of affinity ligands for bioseparation, including the evolution of rational design techniques, dating back to the years of early discovery up to the current and future trends in the field.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitRUNMatos, Manuel J. B.Pina, Ana S.Roque, Ana Cecília A.2022-07-13T22:19:36Z2020-05-202020-05-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/141849eng0021-9673PURE: 17068592https://doi.org/10.1016/j.chroma.2020.460871info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:03:26Zoai:run.unl.pt:10362/141849Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:03:26Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Rational design of affinity ligands for bioseparation |
title |
Rational design of affinity ligands for bioseparation |
spellingShingle |
Rational design of affinity ligands for bioseparation Matos, Manuel J. B. Affinity ligands Bioseparation Downstream processing Molecular recognition Rational design Analytical Chemistry Biochemistry Organic Chemistry |
title_short |
Rational design of affinity ligands for bioseparation |
title_full |
Rational design of affinity ligands for bioseparation |
title_fullStr |
Rational design of affinity ligands for bioseparation |
title_full_unstemmed |
Rational design of affinity ligands for bioseparation |
title_sort |
Rational design of affinity ligands for bioseparation |
author |
Matos, Manuel J. B. |
author_facet |
Matos, Manuel J. B. Pina, Ana S. Roque, Ana Cecília A. |
author_role |
author |
author2 |
Pina, Ana S. Roque, Ana Cecília A. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
DQ - Departamento de Química UCIBIO - Applied Molecular Biosciences Unit RUN |
dc.contributor.author.fl_str_mv |
Matos, Manuel J. B. Pina, Ana S. Roque, Ana Cecília A. |
dc.subject.por.fl_str_mv |
Affinity ligands Bioseparation Downstream processing Molecular recognition Rational design Analytical Chemistry Biochemistry Organic Chemistry |
topic |
Affinity ligands Bioseparation Downstream processing Molecular recognition Rational design Analytical Chemistry Biochemistry Organic Chemistry |
description |
Fundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-20 2020-05-20T00:00:00Z 2022-07-13T22:19:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/141849 |
url |
http://hdl.handle.net/10362/141849 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0021-9673 PURE: 17068592 https://doi.org/10.1016/j.chroma.2020.460871 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545874686869504 |