Rational design of affinity ligands for bioseparation

Detalhes bibliográficos
Autor(a) principal: Matos, Manuel J. B.
Data de Publicação: 2020
Outros Autores: Pina, Ana S., Roque, Ana Cecília A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/141849
Resumo: Fundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM.
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spelling Rational design of affinity ligands for bioseparationAffinity ligandsBioseparationDownstream processingMolecular recognitionRational designAnalytical ChemistryBiochemistryOrganic ChemistryFundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM.Affinity adsorbents have been the cornerstone in protein purification. The selective nature of the molecular recognition interactions established between an affinity ligands and its target provide the basis for efficient capture and isolation of proteins. The plethora of affinity adsorbents available in the market reflects the importance of affinity chromatography in the bioseparation industry. Ligand discovery relies on the implementation of rational design techniques, which provides the foundation for the engineering of novel affinity ligands. The main goal for the design of affinity ligands is to discover or improve functionality, such as increased stability or selectivity. However, the methodologies must adapt to the current needs, namely to the number and diversity of biologicals being developed, and the availability of new tools for big data analysis and artificial intelligence. In this review, we offer an overview on the development of affinity ligands for bioseparation, including the evolution of rational design techniques, dating back to the years of early discovery up to the current and future trends in the field.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitRUNMatos, Manuel J. B.Pina, Ana S.Roque, Ana Cecília A.2022-07-13T22:19:36Z2020-05-202020-05-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/141849eng0021-9673PURE: 17068592https://doi.org/10.1016/j.chroma.2020.460871info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:19:08Zoai:run.unl.pt:10362/141849Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:04.310575Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rational design of affinity ligands for bioseparation
title Rational design of affinity ligands for bioseparation
spellingShingle Rational design of affinity ligands for bioseparation
Matos, Manuel J. B.
Affinity ligands
Bioseparation
Downstream processing
Molecular recognition
Rational design
Analytical Chemistry
Biochemistry
Organic Chemistry
title_short Rational design of affinity ligands for bioseparation
title_full Rational design of affinity ligands for bioseparation
title_fullStr Rational design of affinity ligands for bioseparation
title_full_unstemmed Rational design of affinity ligands for bioseparation
title_sort Rational design of affinity ligands for bioseparation
author Matos, Manuel J. B.
author_facet Matos, Manuel J. B.
Pina, Ana S.
Roque, Ana Cecília A.
author_role author
author2 Pina, Ana S.
Roque, Ana Cecília A.
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Matos, Manuel J. B.
Pina, Ana S.
Roque, Ana Cecília A.
dc.subject.por.fl_str_mv Affinity ligands
Bioseparation
Downstream processing
Molecular recognition
Rational design
Analytical Chemistry
Biochemistry
Organic Chemistry
topic Affinity ligands
Bioseparation
Downstream processing
Molecular recognition
Rational design
Analytical Chemistry
Biochemistry
Organic Chemistry
description Fundação para a Ciência e a Tecnologia PTDC/BII-BIO/28878/2017; European Regional Development Fund - LISBOA-01-0145-FEDER-028878; UID/Multi/04378/2019 Applied Molecular Biosciences Unit PD/BD/128251/2016; POCI-01-0145-FEDER-007728; SFRH/BPD/97585/2013; fellowships PD/BD/128251/2016 from MIT-PT PhD Bioengineering Systems to MM.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-20
2020-05-20T00:00:00Z
2022-07-13T22:19:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/141849
url http://hdl.handle.net/10362/141849
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9673
PURE: 17068592
https://doi.org/10.1016/j.chroma.2020.460871
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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