Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer

Detalhes bibliográficos
Autor(a) principal: Marques, Marcia M.
Data de Publicação: 2018
Outros Autores: Evangelista, Adriane F., Macedo, Taciane, Vieira, René Aloisio da Costa, Scapulatempo-Neto, Cristovam, Reis, R. M., Carvalho, André L., Silva, Ismael Dale Cotrim Guerreiro da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58192
Resumo: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.
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spelling Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancerAdultAgedAnalysis of VarianceBiomarkers, TumorBreast NeoplasmsCarcinogenesisCase-Control StudiesDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansLogistic ModelsMicroRNAsMiddle AgedNeoplasm InvasivenessNeoplasm StagingProspective StudiesReal-Time Polymerase Chain ReactionReference ValuesRisk FactorsSensitivity and SpecificityBreast CancerBiomarkersTumor SuppressorsEarly DetectionCiências Médicas::Medicina BásicaScience & TechnologyMicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.The authors acknowledge the Avon Institute for sponsoring this study. The authors would like to thank the Barretos Cancer Hospital's Research Support Nucleus for patient identification, sample selection, and biostatistics support, as well as Barretos Cancer Hospital's Tumor Bank for sample provision and RNA extraction.info:eu-repo/semantics/publishedVersionUniversidade de São Paulo. Faculdade de MedicinaUniversidade do MinhoMarques, Marcia M.Evangelista, Adriane F.Macedo, TacianeVieira, René Aloisio da CostaScapulatempo-Neto, CristovamReis, R. M.Carvalho, André L.Silva, Ismael Dale Cotrim Guerreiro da20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58192engMarques, M. M., Evangelista, A. F., Macedo, T., Vieira, R. A. D. C., Scapulatempo-Neto, C., Reis, R. M., ... & Silva, I. D. C. G. D. (2018). Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. Clinics, 73.1807-59321980-532210.6061/clinics/2018/e18429995098http://www.scielo.br/scielo.php?script=sci_serial&pid=1807-5932&lng=en&nrm=isoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:18Zoai:repositorium.sdum.uminho.pt:1822/58192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:21.525757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
title Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
spellingShingle Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
Marques, Marcia M.
Adult
Aged
Analysis of Variance
Biomarkers, Tumor
Breast Neoplasms
Carcinogenesis
Case-Control Studies
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Logistic Models
MicroRNAs
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prospective Studies
Real-Time Polymerase Chain Reaction
Reference Values
Risk Factors
Sensitivity and Specificity
Breast Cancer
Biomarkers
Tumor Suppressors
Early Detection
Ciências Médicas::Medicina Básica
Science & Technology
title_short Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
title_full Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
title_fullStr Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
title_full_unstemmed Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
title_sort Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
author Marques, Marcia M.
author_facet Marques, Marcia M.
Evangelista, Adriane F.
Macedo, Taciane
Vieira, René Aloisio da Costa
Scapulatempo-Neto, Cristovam
Reis, R. M.
Carvalho, André L.
Silva, Ismael Dale Cotrim Guerreiro da
author_role author
author2 Evangelista, Adriane F.
Macedo, Taciane
Vieira, René Aloisio da Costa
Scapulatempo-Neto, Cristovam
Reis, R. M.
Carvalho, André L.
Silva, Ismael Dale Cotrim Guerreiro da
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Marques, Marcia M.
Evangelista, Adriane F.
Macedo, Taciane
Vieira, René Aloisio da Costa
Scapulatempo-Neto, Cristovam
Reis, R. M.
Carvalho, André L.
Silva, Ismael Dale Cotrim Guerreiro da
dc.subject.por.fl_str_mv Adult
Aged
Analysis of Variance
Biomarkers, Tumor
Breast Neoplasms
Carcinogenesis
Case-Control Studies
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Logistic Models
MicroRNAs
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prospective Studies
Real-Time Polymerase Chain Reaction
Reference Values
Risk Factors
Sensitivity and Specificity
Breast Cancer
Biomarkers
Tumor Suppressors
Early Detection
Ciências Médicas::Medicina Básica
Science & Technology
topic Adult
Aged
Analysis of Variance
Biomarkers, Tumor
Breast Neoplasms
Carcinogenesis
Case-Control Studies
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Logistic Models
MicroRNAs
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prospective Studies
Real-Time Polymerase Chain Reaction
Reference Values
Risk Factors
Sensitivity and Specificity
Breast Cancer
Biomarkers
Tumor Suppressors
Early Detection
Ciências Médicas::Medicina Básica
Science & Technology
description MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58192
url http://hdl.handle.net/1822/58192
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marques, M. M., Evangelista, A. F., Macedo, T., Vieira, R. A. D. C., Scapulatempo-Neto, C., Reis, R. M., ... & Silva, I. D. C. G. D. (2018). Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. Clinics, 73.
1807-5932
1980-5322
10.6061/clinics/2018/e184
29995098
http://www.scielo.br/scielo.php?script=sci_serial&pid=1807-5932&lng=en&nrm=iso
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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