Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/58192 |
Resumo: | MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer. |
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Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancerAdultAgedAnalysis of VarianceBiomarkers, TumorBreast NeoplasmsCarcinogenesisCase-Control StudiesDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansLogistic ModelsMicroRNAsMiddle AgedNeoplasm InvasivenessNeoplasm StagingProspective StudiesReal-Time Polymerase Chain ReactionReference ValuesRisk FactorsSensitivity and SpecificityBreast CancerBiomarkersTumor SuppressorsEarly DetectionCiências Médicas::Medicina BásicaScience & TechnologyMicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.The authors acknowledge the Avon Institute for sponsoring this study. The authors would like to thank the Barretos Cancer Hospital's Research Support Nucleus for patient identification, sample selection, and biostatistics support, as well as Barretos Cancer Hospital's Tumor Bank for sample provision and RNA extraction.info:eu-repo/semantics/publishedVersionUniversidade de São Paulo. Faculdade de MedicinaUniversidade do MinhoMarques, Marcia M.Evangelista, Adriane F.Macedo, TacianeVieira, René Aloisio da CostaScapulatempo-Neto, CristovamReis, R. M.Carvalho, André L.Silva, Ismael Dale Cotrim Guerreiro da20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58192engMarques, M. M., Evangelista, A. F., Macedo, T., Vieira, R. A. D. C., Scapulatempo-Neto, C., Reis, R. M., ... & Silva, I. D. C. G. D. (2018). Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. Clinics, 73.1807-59321980-532210.6061/clinics/2018/e18429995098http://www.scielo.br/scielo.php?script=sci_serial&pid=1807-5932&lng=en&nrm=isoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:18Zoai:repositorium.sdum.uminho.pt:1822/58192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:21.525757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
title |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
spellingShingle |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer Marques, Marcia M. Adult Aged Analysis of Variance Biomarkers, Tumor Breast Neoplasms Carcinogenesis Case-Control Studies Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Logistic Models MicroRNAs Middle Aged Neoplasm Invasiveness Neoplasm Staging Prospective Studies Real-Time Polymerase Chain Reaction Reference Values Risk Factors Sensitivity and Specificity Breast Cancer Biomarkers Tumor Suppressors Early Detection Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
title_full |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
title_fullStr |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
title_full_unstemmed |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
title_sort |
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer |
author |
Marques, Marcia M. |
author_facet |
Marques, Marcia M. Evangelista, Adriane F. Macedo, Taciane Vieira, René Aloisio da Costa Scapulatempo-Neto, Cristovam Reis, R. M. Carvalho, André L. Silva, Ismael Dale Cotrim Guerreiro da |
author_role |
author |
author2 |
Evangelista, Adriane F. Macedo, Taciane Vieira, René Aloisio da Costa Scapulatempo-Neto, Cristovam Reis, R. M. Carvalho, André L. Silva, Ismael Dale Cotrim Guerreiro da |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Marques, Marcia M. Evangelista, Adriane F. Macedo, Taciane Vieira, René Aloisio da Costa Scapulatempo-Neto, Cristovam Reis, R. M. Carvalho, André L. Silva, Ismael Dale Cotrim Guerreiro da |
dc.subject.por.fl_str_mv |
Adult Aged Analysis of Variance Biomarkers, Tumor Breast Neoplasms Carcinogenesis Case-Control Studies Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Logistic Models MicroRNAs Middle Aged Neoplasm Invasiveness Neoplasm Staging Prospective Studies Real-Time Polymerase Chain Reaction Reference Values Risk Factors Sensitivity and Specificity Breast Cancer Biomarkers Tumor Suppressors Early Detection Ciências Médicas::Medicina Básica Science & Technology |
topic |
Adult Aged Analysis of Variance Biomarkers, Tumor Breast Neoplasms Carcinogenesis Case-Control Studies Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Logistic Models MicroRNAs Middle Aged Neoplasm Invasiveness Neoplasm Staging Prospective Studies Real-Time Polymerase Chain Reaction Reference Values Risk Factors Sensitivity and Specificity Breast Cancer Biomarkers Tumor Suppressors Early Detection Ciências Médicas::Medicina Básica Science & Technology |
description |
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/58192 |
url |
http://hdl.handle.net/1822/58192 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, M. M., Evangelista, A. F., Macedo, T., Vieira, R. A. D. C., Scapulatempo-Neto, C., Reis, R. M., ... & Silva, I. D. C. G. D. (2018). Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. Clinics, 73. 1807-5932 1980-5322 10.6061/clinics/2018/e184 29995098 http://www.scielo.br/scielo.php?script=sci_serial&pid=1807-5932&lng=en&nrm=iso |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132465288183808 |