Approaches and Perspectives for Development of African Swine Fever Virus Vaccines

Detalhes bibliográficos
Autor(a) principal: Arias, Marisa
Data de Publicação: 2017
Outros Autores: de la Torre, Ana, Dixon, Linda, Gallardo, Carmina, Jori, Ferran, Laddomada, Alberto, Martins, Carlos, Parkhouse, R. Michael, Revilla, Yolanda, Rodriguez, Fernando and Jose-Manuel, Sanchez-Vizcaino, null
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/792
Resumo: There is no public supplementary material available. There is no public supplementary material available.
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spelling Approaches and Perspectives for Development of African Swine Fever Virus VaccinesAfrican swine fevervaccineimmunologyvaccine gapsThere is no public supplementary material available. There is no public supplementary material available.African swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. The disease shows variable clinical signs, with high case fatality rates, up to 100%, in the acute forms. ASF is currently present in Africa and Europe where it circulates in different scenarios causing a high socio-economic impact. In most affected regions, control has not been effective in part due to lack of a vaccine. The availability of an effective and safe ASFV vaccines would support and enforce control-eradication strategies. Therefore, work leading to the rational development of protective ASF vaccines is a high priority. Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. Many of these virus proteins inhibit the host's immune system thus facilitating virus replication and persistence. We review previous work aimed at understanding ASFV-host interactions, including mechanisms of protective immunity, and approaches for vaccine development. These include live attenuated vaccines, and "subunit" vaccines, based on DNA, proteins, or virus vectors. In the shorter to medium term, live attenuated vaccines are the most promising and best positioned candidates. Gaps and future research directions are evaluated.European Commision Directorate-General SANTE "Health and Food Safety"; European Union Reference Laboratory Grant 2016–2017.MDPIARCAArias, Marisade la Torre, AnaDixon, LindaGallardo, CarminaJori, FerranLaddomada, AlbertoMartins, CarlosParkhouse, R. MichaelRevilla, YolandaRodriguez, Fernando and Jose-ManuelSanchez-Vizcaino, null2017-10-23T16:05:18Z2017-10-072017-10-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/792engArias, M.; de la Torre, A.; Dixon, L.; Gallardo, C.; Jori, F.; Laddomada, A.; Martins, C.; Parkhouse, R.M.; Revilla, Y.; Rodriguez, F.-M.; Sanchez-Vizcaino. Approaches and Perspectives for Development of African Swine Fever Virus Vaccines. Vaccines 2017, 5, 35.10.3390/vaccines5040035info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:12Zoai:arca.igc.gulbenkian.pt:10400.7/792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:01.021152Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
title Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
spellingShingle Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
Arias, Marisa
African swine fever
vaccine
immunology
vaccine gaps
title_short Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
title_full Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
title_fullStr Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
title_full_unstemmed Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
title_sort Approaches and Perspectives for Development of African Swine Fever Virus Vaccines
author Arias, Marisa
author_facet Arias, Marisa
de la Torre, Ana
Dixon, Linda
Gallardo, Carmina
Jori, Ferran
Laddomada, Alberto
Martins, Carlos
Parkhouse, R. Michael
Revilla, Yolanda
Rodriguez, Fernando and Jose-Manuel
Sanchez-Vizcaino, null
author_role author
author2 de la Torre, Ana
Dixon, Linda
Gallardo, Carmina
Jori, Ferran
Laddomada, Alberto
Martins, Carlos
Parkhouse, R. Michael
Revilla, Yolanda
Rodriguez, Fernando and Jose-Manuel
Sanchez-Vizcaino, null
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Arias, Marisa
de la Torre, Ana
Dixon, Linda
Gallardo, Carmina
Jori, Ferran
Laddomada, Alberto
Martins, Carlos
Parkhouse, R. Michael
Revilla, Yolanda
Rodriguez, Fernando and Jose-Manuel
Sanchez-Vizcaino, null
dc.subject.por.fl_str_mv African swine fever
vaccine
immunology
vaccine gaps
topic African swine fever
vaccine
immunology
vaccine gaps
description There is no public supplementary material available. There is no public supplementary material available.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-23T16:05:18Z
2017-10-07
2017-10-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/792
url http://hdl.handle.net/10400.7/792
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arias, M.; de la Torre, A.; Dixon, L.; Gallardo, C.; Jori, F.; Laddomada, A.; Martins, C.; Parkhouse, R.M.; Revilla, Y.; Rodriguez, F.-M.; Sanchez-Vizcaino. Approaches and Perspectives for Development of African Swine Fever Virus Vaccines. Vaccines 2017, 5, 35.
10.3390/vaccines5040035
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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