Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

Detalhes bibliográficos
Autor(a) principal: Lovey, Arianne
Data de Publicação: 2022
Outros Autores: Verma, Sheetal, Kaipilyawar, Vaishnavi, Ribeiro-Rodrigues, Rodrigo, Husain, Seema, Palaci, Moises, Dietze, Reynaldo, Ma, Shuyi, Morrison, Robert D., Sherman, David R., Ellner, Jerrold J., Salgame, Padmini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/148172
Resumo: Funding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).
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spelling Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strainsMycobacterium tuberculosistransmission mechanismsalveolar macrophagesimune responseRA0421 Public health. Hygiene. Preventive MedicineQR180 ImmunologyChemistry(all)Biochemistry, Genetics and Molecular Biology(all)GeneralPhysics and Astronomy(all)ImmunologyMicrobiologySDG 3 - Good Health and Well-beingFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent temporal events of early dissemination of bacteria to the lymph nodes, Th1 priming, granulomatous response and bacterial control. In contrast, IL-1R-dependent alveolar macrophage migration and early dissemination of bacteria to lymph nodes is significantly impeded in infection with low transmission M.tuberculosis strain; these events promote the development of Th17 immunity, fostering neutrophilic inflammation and increased bacterial replication. Our results suggest that by inducing granulomas with the potential to develop into cavitary lesions that aids bacterial escape into the airways, high transmission M.tuberculosis strain is poised for greater transmissibility. These findings implicate bacterial heterogeneity as an important modifier of TB disease manifestations and transmission.Instituto de Higiene e Medicina Tropical (IHMT)Individual Health Care (IHC)Global Health and Tropical Medicine (GHTM)Universidade NOVA de LisboaRUNLovey, ArianneVerma, SheetalKaipilyawar, VaishnaviRibeiro-Rodrigues, RodrigoHusain, SeemaPalaci, MoisesDietze, ReynaldoMa, ShuyiMorrison, Robert D.Sherman, David R.Ellner, Jerrold J.Salgame, Padmini2023-01-25T22:16:52Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148172eng2041-1723PURE: 50657009https://doi.org/10.1038/s41467-022-28506-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:33Zoai:run.unl.pt:10362/148172Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:13.907812Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
title Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
spellingShingle Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Lovey, Arianne
Mycobacterium tuberculosis
transmission mechanisms
alveolar macrophages
imune response
RA0421 Public health. Hygiene. Preventive Medicine
QR180 Immunology
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)
Immunology
Microbiology
SDG 3 - Good Health and Well-being
title_short Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
title_full Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
title_fullStr Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
title_full_unstemmed Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
title_sort Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
author Lovey, Arianne
author_facet Lovey, Arianne
Verma, Sheetal
Kaipilyawar, Vaishnavi
Ribeiro-Rodrigues, Rodrigo
Husain, Seema
Palaci, Moises
Dietze, Reynaldo
Ma, Shuyi
Morrison, Robert D.
Sherman, David R.
Ellner, Jerrold J.
Salgame, Padmini
author_role author
author2 Verma, Sheetal
Kaipilyawar, Vaishnavi
Ribeiro-Rodrigues, Rodrigo
Husain, Seema
Palaci, Moises
Dietze, Reynaldo
Ma, Shuyi
Morrison, Robert D.
Sherman, David R.
Ellner, Jerrold J.
Salgame, Padmini
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Individual Health Care (IHC)
Global Health and Tropical Medicine (GHTM)
Universidade NOVA de Lisboa
RUN
dc.contributor.author.fl_str_mv Lovey, Arianne
Verma, Sheetal
Kaipilyawar, Vaishnavi
Ribeiro-Rodrigues, Rodrigo
Husain, Seema
Palaci, Moises
Dietze, Reynaldo
Ma, Shuyi
Morrison, Robert D.
Sherman, David R.
Ellner, Jerrold J.
Salgame, Padmini
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
transmission mechanisms
alveolar macrophages
imune response
RA0421 Public health. Hygiene. Preventive Medicine
QR180 Immunology
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)
Immunology
Microbiology
SDG 3 - Good Health and Well-being
topic Mycobacterium tuberculosis
transmission mechanisms
alveolar macrophages
imune response
RA0421 Public health. Hygiene. Preventive Medicine
QR180 Immunology
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)
Immunology
Microbiology
SDG 3 - Good Health and Well-being
description Funding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).
publishDate 2022
dc.date.none.fl_str_mv 2022-12
2022-12-01T00:00:00Z
2023-01-25T22:16:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/148172
url http://hdl.handle.net/10362/148172
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2041-1723
PURE: 50657009
https://doi.org/10.1038/s41467-022-28506-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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