Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/148172 |
Resumo: | Funding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s). |
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Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strainsMycobacterium tuberculosistransmission mechanismsalveolar macrophagesimune responseRA0421 Public health. Hygiene. Preventive MedicineQR180 ImmunologyChemistry(all)Biochemistry, Genetics and Molecular Biology(all)GeneralPhysics and Astronomy(all)ImmunologyMicrobiologySDG 3 - Good Health and Well-beingFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent temporal events of early dissemination of bacteria to the lymph nodes, Th1 priming, granulomatous response and bacterial control. In contrast, IL-1R-dependent alveolar macrophage migration and early dissemination of bacteria to lymph nodes is significantly impeded in infection with low transmission M.tuberculosis strain; these events promote the development of Th17 immunity, fostering neutrophilic inflammation and increased bacterial replication. Our results suggest that by inducing granulomas with the potential to develop into cavitary lesions that aids bacterial escape into the airways, high transmission M.tuberculosis strain is poised for greater transmissibility. These findings implicate bacterial heterogeneity as an important modifier of TB disease manifestations and transmission.Instituto de Higiene e Medicina Tropical (IHMT)Individual Health Care (IHC)Global Health and Tropical Medicine (GHTM)Universidade NOVA de LisboaRUNLovey, ArianneVerma, SheetalKaipilyawar, VaishnaviRibeiro-Rodrigues, RodrigoHusain, SeemaPalaci, MoisesDietze, ReynaldoMa, ShuyiMorrison, Robert D.Sherman, David R.Ellner, Jerrold J.Salgame, Padmini2023-01-25T22:16:52Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148172eng2041-1723PURE: 50657009https://doi.org/10.1038/s41467-022-28506-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:33Zoai:run.unl.pt:10362/148172Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:13.907812Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
title |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
spellingShingle |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains Lovey, Arianne Mycobacterium tuberculosis transmission mechanisms alveolar macrophages imune response RA0421 Public health. Hygiene. Preventive Medicine QR180 Immunology Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) General Physics and Astronomy(all) Immunology Microbiology SDG 3 - Good Health and Well-being |
title_short |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
title_full |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
title_fullStr |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
title_full_unstemmed |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
title_sort |
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains |
author |
Lovey, Arianne |
author_facet |
Lovey, Arianne Verma, Sheetal Kaipilyawar, Vaishnavi Ribeiro-Rodrigues, Rodrigo Husain, Seema Palaci, Moises Dietze, Reynaldo Ma, Shuyi Morrison, Robert D. Sherman, David R. Ellner, Jerrold J. Salgame, Padmini |
author_role |
author |
author2 |
Verma, Sheetal Kaipilyawar, Vaishnavi Ribeiro-Rodrigues, Rodrigo Husain, Seema Palaci, Moises Dietze, Reynaldo Ma, Shuyi Morrison, Robert D. Sherman, David R. Ellner, Jerrold J. Salgame, Padmini |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Individual Health Care (IHC) Global Health and Tropical Medicine (GHTM) Universidade NOVA de Lisboa RUN |
dc.contributor.author.fl_str_mv |
Lovey, Arianne Verma, Sheetal Kaipilyawar, Vaishnavi Ribeiro-Rodrigues, Rodrigo Husain, Seema Palaci, Moises Dietze, Reynaldo Ma, Shuyi Morrison, Robert D. Sherman, David R. Ellner, Jerrold J. Salgame, Padmini |
dc.subject.por.fl_str_mv |
Mycobacterium tuberculosis transmission mechanisms alveolar macrophages imune response RA0421 Public health. Hygiene. Preventive Medicine QR180 Immunology Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) General Physics and Astronomy(all) Immunology Microbiology SDG 3 - Good Health and Well-being |
topic |
Mycobacterium tuberculosis transmission mechanisms alveolar macrophages imune response RA0421 Public health. Hygiene. Preventive Medicine QR180 Immunology Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) General Physics and Astronomy(all) Immunology Microbiology SDG 3 - Good Health and Well-being |
description |
Funding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12 2022-12-01T00:00:00Z 2023-01-25T22:16:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/148172 |
url |
http://hdl.handle.net/10362/148172 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 PURE: 50657009 https://doi.org/10.1038/s41467-022-28506-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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