Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/43453 |
Resumo: | Background: Marine-derived natural products have been attracting attention from both the food and pharmaceutical sectors due to their promising therapeutic attributes. Algae and their biomolecules are examples of marine-derived products for ongoing research endeavors. Fucoidan, an algae-derived polysaccharide, has emerged as a recent biomolecule related to a diverse array of beneficial properties, with particular emphasis on its neuroprotective activities. Scope and approach: This review intended to understand the neuroprotective properties of Fucoidan and its impact on brain disorders. Fucoidan has risen to prominence as one of the most promising neuroprotective agents obtained from macroalgae, with in vitro and in vivo studies proving its efficiency. Nevertheless, the extant literature underscores the imperative for further clinical trials to substantiate its therapeutic prowess. The neuroprotective effect of fucoidan is related to oxidative stress, mitochondrial function, neuroinflammation, apoptosis, as well as the interaction between gut-brain-microbiota. Key findings and conclusions: Despite having numerous health benefits being approved by regulatory entities, fucoidan products consumption, and use by industry still needs to be explored. Henceforth, there is a need to search for an efficient method for the successful commercialization of fucoidan, focusing on its suitable dosage for pharmaceutical and nutraceutical applications, but it is also necessary to have clinical studies proving its efficacy in brain disorders. Therefore, this biomolecule has the potential to be exploited by researchers, investors and consumers. In this way, fucoidan could contribute to the promotion and improvement of society’s quality of life concerning specific brain pathologies. |
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Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disordersMacroalgaeBioactive compoundsNew moleculesSustainabilityBrain benefitsBackground: Marine-derived natural products have been attracting attention from both the food and pharmaceutical sectors due to their promising therapeutic attributes. Algae and their biomolecules are examples of marine-derived products for ongoing research endeavors. Fucoidan, an algae-derived polysaccharide, has emerged as a recent biomolecule related to a diverse array of beneficial properties, with particular emphasis on its neuroprotective activities. Scope and approach: This review intended to understand the neuroprotective properties of Fucoidan and its impact on brain disorders. Fucoidan has risen to prominence as one of the most promising neuroprotective agents obtained from macroalgae, with in vitro and in vivo studies proving its efficiency. Nevertheless, the extant literature underscores the imperative for further clinical trials to substantiate its therapeutic prowess. The neuroprotective effect of fucoidan is related to oxidative stress, mitochondrial function, neuroinflammation, apoptosis, as well as the interaction between gut-brain-microbiota. Key findings and conclusions: Despite having numerous health benefits being approved by regulatory entities, fucoidan products consumption, and use by industry still needs to be explored. Henceforth, there is a need to search for an efficient method for the successful commercialization of fucoidan, focusing on its suitable dosage for pharmaceutical and nutraceutical applications, but it is also necessary to have clinical studies proving its efficacy in brain disorders. Therefore, this biomolecule has the potential to be exploited by researchers, investors and consumers. In this way, fucoidan could contribute to the promotion and improvement of society’s quality of life concerning specific brain pathologies.Veritati - Repositório Institucional da Universidade Católica PortuguesaBatista, PatríciaCunha, Sara A.Ribeiro, TâniaBorges, SandraBaptista-Silva, SaraOliveira-Silva, PatríciaPintado, Manuela2024-01-03T12:01:19Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/43453eng0924-224410.1016/j.tifs.2023.10430085182414865001148285200001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-13T01:33:39Zoai:repositorio.ucp.pt:10400.14/43453Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:51.544830Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
title |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
spellingShingle |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders Batista, Patrícia Macroalgae Bioactive compounds New molecules Sustainability Brain benefits |
title_short |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
title_full |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
title_fullStr |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
title_full_unstemmed |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
title_sort |
Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders |
author |
Batista, Patrícia |
author_facet |
Batista, Patrícia Cunha, Sara A. Ribeiro, Tânia Borges, Sandra Baptista-Silva, Sara Oliveira-Silva, Patrícia Pintado, Manuela |
author_role |
author |
author2 |
Cunha, Sara A. Ribeiro, Tânia Borges, Sandra Baptista-Silva, Sara Oliveira-Silva, Patrícia Pintado, Manuela |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Batista, Patrícia Cunha, Sara A. Ribeiro, Tânia Borges, Sandra Baptista-Silva, Sara Oliveira-Silva, Patrícia Pintado, Manuela |
dc.subject.por.fl_str_mv |
Macroalgae Bioactive compounds New molecules Sustainability Brain benefits |
topic |
Macroalgae Bioactive compounds New molecules Sustainability Brain benefits |
description |
Background: Marine-derived natural products have been attracting attention from both the food and pharmaceutical sectors due to their promising therapeutic attributes. Algae and their biomolecules are examples of marine-derived products for ongoing research endeavors. Fucoidan, an algae-derived polysaccharide, has emerged as a recent biomolecule related to a diverse array of beneficial properties, with particular emphasis on its neuroprotective activities. Scope and approach: This review intended to understand the neuroprotective properties of Fucoidan and its impact on brain disorders. Fucoidan has risen to prominence as one of the most promising neuroprotective agents obtained from macroalgae, with in vitro and in vivo studies proving its efficiency. Nevertheless, the extant literature underscores the imperative for further clinical trials to substantiate its therapeutic prowess. The neuroprotective effect of fucoidan is related to oxidative stress, mitochondrial function, neuroinflammation, apoptosis, as well as the interaction between gut-brain-microbiota. Key findings and conclusions: Despite having numerous health benefits being approved by regulatory entities, fucoidan products consumption, and use by industry still needs to be explored. Henceforth, there is a need to search for an efficient method for the successful commercialization of fucoidan, focusing on its suitable dosage for pharmaceutical and nutraceutical applications, but it is also necessary to have clinical studies proving its efficacy in brain disorders. Therefore, this biomolecule has the potential to be exploited by researchers, investors and consumers. In this way, fucoidan could contribute to the promotion and improvement of society’s quality of life concerning specific brain pathologies. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-03T12:01:19Z 2024-01 2024-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/43453 |
url |
http://hdl.handle.net/10400.14/43453 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0924-2244 10.1016/j.tifs.2023.104300 85182414865 001148285200001 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136790409379840 |