Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders

• Autor(a) principal: Batista, Patrícia
• Data de Publicação: 2024
• Outros Autores: Cunha, Sara A., Ribeiro, Tânia, Borges, Sandra, Baptista-Silva, Sara, Oliveira-Silva, Patrícia, Pintado, Manuela
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.14/43453
• topic: Macroalgae; Bioactive compounds; New molecules; Sustainability; Brain benefits

Background: Marine-derived natural products have been attracting attention from both the food and pharmaceutical sectors due to their promising therapeutic attributes. Algae and their biomolecules are examples of marine-derived products for ongoing research endeavors. Fucoidan, an algae-derived polysaccharide, has emerged as a recent biomolecule related to a diverse array of beneficial properties, with particular emphasis on its neuroprotective activities. Scope and approach: This review intended to understand the neuroprotective properties of Fucoidan and its impact on brain disorders. Fucoidan has risen to prominence as one of the most promising neuroprotective agents obtained from macroalgae, with in vitro and in vivo studies proving its efficiency. Nevertheless, the extant literature underscores the imperative for further clinical trials to substantiate its therapeutic prowess. The neuroprotective effect of fucoidan is related to oxidative stress, mitochondrial function, neuroinflammation, apoptosis, as well as the interaction between gut-brain-microbiota. Key findings and conclusions: Despite having numerous health benefits being approved by regulatory entities, fucoidan products consumption, and use by industry still needs to be explored. Henceforth, there is a need to search for an efficient method for the successful commercialization of fucoidan, focusing on its suitable dosage for pharmaceutical and nutraceutical applications, but it is also necessary to have clinical studies proving its efficacy in brain disorders. Therefore, this biomolecule has the potential to be exploited by researchers, investors and consumers. In this way, fucoidan could contribute to the promotion and improvement of society’s quality of life concerning specific brain pathologies.