Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood

Detalhes bibliográficos
Autor(a) principal: MINA-Brazil Study Working Group
Data de Publicação: 2022
Outros Autores: Pincelli, Anaclara, Cardoso, Marly A, Malta, Maíra B, Nicolete, Vanessa C, Soares, Irene S, Castro, Marcia C, Ferreira, Marcelo U
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143760
Resumo: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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spelling Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early ChildhoodA Birth Cohort StudyInfectious DiseasesEpidemiologySDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesCopyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.BACKGROUND: Relatively few Amazonian infants have clinical malaria diagnosed, treated and notified before their first birthday, either because they are little exposed to an infection or remain asymptomatic once infected. Here we measure the proportion of children who have experienced Plasmodium vivax infection and malaria by 2 years of age in the main transmission hotspot of Amazonian Brazil. METHODS: We measured IgG antibodies to 3 blood-stage P. vivax antigens at the 1- and 2-year follow-up assessment of 435 participants in a population-based birth cohort. Children's malaria case notifications were retrieved from the electronic database of the Ministry of Health. We used multiple Poisson regression models to identify predictors of serologically proven P. vivax infection and clinical vivax malaria during the first 2 years of life. RESULTS: Overall, 23 [5.3%; 95% confidence interval (CI): 3.5-7.8%) children had antibodies to ≥2 antigens detected during at least one follow-up assessment, consistent with past P. vivax infection(s). Fifteen (3.4%; 95% CI: 2.1-5.6%) children had clinical vivax episodes notified during the first 2 years of life; 7 of them were seronegative. We estimate that half of the infections remained unnotified. Children born to women who experienced P. vivax infection during pregnancy were more likely to be infected and develop clinical vivax malaria, while those breast-fed for ≥12 months had their risk of being P. vivax-seropositive (which we take as evidence of blood-stage P. vivax infection during the first 2 years of life) decreased by 79.8% (95% CI: 69.3-86.7%). CONCLUSION: P. vivax infections in early childhood are underreported in the Amazon, are associated with anemia at 2 years of age, and appear to be partially prevented by prolonged breastfeeding.Individual Health Care (IHC)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNMINA-Brazil Study Working GroupPincelli, AnaclaraCardoso, Marly AMalta, Maíra BNicolete, Vanessa CSoares, Irene SCastro, Marcia CFerreira, Marcelo U2022-09-15T22:43:32Z2022-06-172022-06-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143760eng0891-3668PURE: 46487561https://doi.org/10.1097/INF.0000000000003618info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:22:28Zoai:run.unl.pt:10362/143760Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:07.719197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
A Birth Cohort Study
title Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
spellingShingle Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
MINA-Brazil Study Working Group
Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
title_short Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
title_full Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
title_fullStr Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
title_full_unstemmed Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
title_sort Prolonged Breastfeeding and the Risk of Plasmodium vivax Infection and Clinical Malaria in Early Childhood
author MINA-Brazil Study Working Group
author_facet MINA-Brazil Study Working Group
Pincelli, Anaclara
Cardoso, Marly A
Malta, Maíra B
Nicolete, Vanessa C
Soares, Irene S
Castro, Marcia C
Ferreira, Marcelo U
author_role author
author2 Pincelli, Anaclara
Cardoso, Marly A
Malta, Maíra B
Nicolete, Vanessa C
Soares, Irene S
Castro, Marcia C
Ferreira, Marcelo U
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Individual Health Care (IHC)
Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
RUN
dc.contributor.author.fl_str_mv MINA-Brazil Study Working Group
Pincelli, Anaclara
Cardoso, Marly A
Malta, Maíra B
Nicolete, Vanessa C
Soares, Irene S
Castro, Marcia C
Ferreira, Marcelo U
dc.subject.por.fl_str_mv Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
topic Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
description Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-15T22:43:32Z
2022-06-17
2022-06-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143760
url http://hdl.handle.net/10362/143760
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0891-3668
PURE: 46487561
https://doi.org/10.1097/INF.0000000000003618
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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