Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy

Detalhes bibliográficos
Autor(a) principal: Rocha, Lucie da
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/130072
Resumo: "Milk and its derivatives are important worldwide food sources, particularly for infant nutrition, but face a major health complication: some of their proteins are allergens, especially β-lactoglobulin (BLG), a major component of bovine milk. The fate of BLG upon ingestion remains unsettled, being unclear how extensive BLG proteolysis is and how it affects allergenicity. The fact that proteolytic resistance and antigenic response remain related even for non-oral administration suggests that they are not causally related but rather reflect an underlying common feature.(...)"
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spelling Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapyβ-lactoglobulinaalergéniodimerizaçãocomportamento sensível ao pHBiochemistry for Health"Milk and its derivatives are important worldwide food sources, particularly for infant nutrition, but face a major health complication: some of their proteins are allergens, especially β-lactoglobulin (BLG), a major component of bovine milk. The fate of BLG upon ingestion remains unsettled, being unclear how extensive BLG proteolysis is and how it affects allergenicity. The fact that proteolytic resistance and antigenic response remain related even for non-oral administration suggests that they are not causally related but rather reflect an underlying common feature.(...)"Baptista, AntónioCampos, SaraRUNRocha, Lucie da2022-01-02T01:01:22Z2018-06-112018-042018-06-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/130072enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:53Zoai:run.unl.pt:10362/130072Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:41.560933Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
title Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
spellingShingle Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
Rocha, Lucie da
β-lactoglobulina
alergénio
dimerização
comportamento sensível ao pH
Biochemistry for Health
title_short Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
title_full Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
title_fullStr Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
title_full_unstemmed Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
title_sort Molecular modeling study of β-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
author Rocha, Lucie da
author_facet Rocha, Lucie da
author_role author
dc.contributor.none.fl_str_mv Baptista, António
Campos, Sara
RUN
dc.contributor.author.fl_str_mv Rocha, Lucie da
dc.subject.por.fl_str_mv β-lactoglobulina
alergénio
dimerização
comportamento sensível ao pH
Biochemistry for Health
topic β-lactoglobulina
alergénio
dimerização
comportamento sensível ao pH
Biochemistry for Health
description "Milk and its derivatives are important worldwide food sources, particularly for infant nutrition, but face a major health complication: some of their proteins are allergens, especially β-lactoglobulin (BLG), a major component of bovine milk. The fate of BLG upon ingestion remains unsettled, being unclear how extensive BLG proteolysis is and how it affects allergenicity. The fact that proteolytic resistance and antigenic response remain related even for non-oral administration suggests that they are not causally related but rather reflect an underlying common feature.(...)"
publishDate 2018
dc.date.none.fl_str_mv 2018-06-11
2018-04
2018-06-11T00:00:00Z
2022-01-02T01:01:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/130072
url http://hdl.handle.net/10362/130072
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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