Development of the genetic code: insights from a fungal codon reassignment

Detalhes bibliográficos
Autor(a) principal: Moura, Gabriela R.
Data de Publicação: 2010
Outros Autores: Paredes, João A., Santos, Manuel A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/27657
Resumo: The high conservation of the genetic code and its fundamental role in genome decoding suggest that its evolution is highly restricted or even frozen. However, various prokaryotic and eukaryotic genetic code alterations, several alternative tRNA-dependent amino acid biosynthesis pathways, regulation of tRNA decoding by diverse nucleoside modifications and recent in vivo incorporation of non-natural amino acids into prokaryotic and eukaryotic proteins, show that the code evolves and is surprisingly flexible. The cellular mechanisms and the proteome buffering capacity that support such evolutionary processes remain unclear. Here we explore the hypothesis that codon misreading and reassignment played fundamental roles in the development of the genetic code and we show how a fungal codon reassignment is enlightening its evolution.
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spelling Development of the genetic code: insights from a fungal codon reassignmentGenetic codeProtein synthesistRNAMistranslationCodon reassignmentCodon usageEvolutionCandidaThe high conservation of the genetic code and its fundamental role in genome decoding suggest that its evolution is highly restricted or even frozen. However, various prokaryotic and eukaryotic genetic code alterations, several alternative tRNA-dependent amino acid biosynthesis pathways, regulation of tRNA decoding by diverse nucleoside modifications and recent in vivo incorporation of non-natural amino acids into prokaryotic and eukaryotic proteins, show that the code evolves and is surprisingly flexible. The cellular mechanisms and the proteome buffering capacity that support such evolutionary processes remain unclear. Here we explore the hypothesis that codon misreading and reassignment played fundamental roles in the development of the genetic code and we show how a fungal codon reassignment is enlightening its evolution.Elsevier2020-02-26T12:10:07Z2010-01-21T00:00:00Z2010-01-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27657eng0014-579310.1016/j.febslet.2009.11.066Moura, Gabriela R.Paredes, João A.Santos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:35Zoai:ria.ua.pt:10773/27657Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:22.872855Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of the genetic code: insights from a fungal codon reassignment
title Development of the genetic code: insights from a fungal codon reassignment
spellingShingle Development of the genetic code: insights from a fungal codon reassignment
Moura, Gabriela R.
Genetic code
Protein synthesist
RNA
Mistranslation
Codon reassignment
Codon usage
Evolution
Candida
title_short Development of the genetic code: insights from a fungal codon reassignment
title_full Development of the genetic code: insights from a fungal codon reassignment
title_fullStr Development of the genetic code: insights from a fungal codon reassignment
title_full_unstemmed Development of the genetic code: insights from a fungal codon reassignment
title_sort Development of the genetic code: insights from a fungal codon reassignment
author Moura, Gabriela R.
author_facet Moura, Gabriela R.
Paredes, João A.
Santos, Manuel A. S.
author_role author
author2 Paredes, João A.
Santos, Manuel A. S.
author2_role author
author
dc.contributor.author.fl_str_mv Moura, Gabriela R.
Paredes, João A.
Santos, Manuel A. S.
dc.subject.por.fl_str_mv Genetic code
Protein synthesist
RNA
Mistranslation
Codon reassignment
Codon usage
Evolution
Candida
topic Genetic code
Protein synthesist
RNA
Mistranslation
Codon reassignment
Codon usage
Evolution
Candida
description The high conservation of the genetic code and its fundamental role in genome decoding suggest that its evolution is highly restricted or even frozen. However, various prokaryotic and eukaryotic genetic code alterations, several alternative tRNA-dependent amino acid biosynthesis pathways, regulation of tRNA decoding by diverse nucleoside modifications and recent in vivo incorporation of non-natural amino acids into prokaryotic and eukaryotic proteins, show that the code evolves and is surprisingly flexible. The cellular mechanisms and the proteome buffering capacity that support such evolutionary processes remain unclear. Here we explore the hypothesis that codon misreading and reassignment played fundamental roles in the development of the genetic code and we show how a fungal codon reassignment is enlightening its evolution.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-21T00:00:00Z
2010-01-21
2020-02-26T12:10:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/27657
url http://hdl.handle.net/10773/27657
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0014-5793
10.1016/j.febslet.2009.11.066
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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