Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study

Detalhes bibliográficos
Autor(a) principal: Mesquita, Rui
Data de Publicação: 2002
Outros Autores: Piçarra, Bruno, Saldanha, Carlota, Martins e Silva, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/17749
Resumo: © 2002 – IOS Press. All rights reserved.
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spelling Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study© 2002 – IOS Press. All rights reserved.NO is present in the blood at 10−7 M under physiological conditions, but at concentrations higher than 10−6 M during inflammatory disease states. The aim of this study was to characterize what are the effects of these different NO concentrations on erythrocyte structural and functional properties. Blood was collected from eleven healthy men and incubated with SpermineNONOate in order to expose it during incubation time to NO concentrations between 10−7 M and 10−3 M. We measured erythrocyte aggregation and deformability, membrane lipid peroxidation and fluidity, p50, hemoglobin, oxyhemoglobin, methemoglobin concentrations and plasma pH, pO2, pCO2, Na+, K+ and Ca2+. When blood was exposed to NO 10−7 M erythrocyte deformability increase and p50 decrease. In presence of NO 10−5 M lipid fluidity and p50 decrease. When blood was exposed to NO 10−3 M methemoglobin concentration increase and erythrocyte deformability and p50 decrease but membrane fluidity and lipid peroxidation were similar to control. In conclusion, dependent of NO concentrations there is different effects on erythrocytes structural and functional properties.IOS PressRepositório da Universidade de LisboaMesquita, RuiPiçarra, BrunoSaldanha, CarlotaMartins e Silva, J.2015-03-19T11:20:55Z20022002-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17749engClinical Hemorheology and Microcirculation 27 (2002) 137–1471386-0291http://iospress.metapress.com/content/l2d3rg10j85yeqjq/?p=6f43ad018c42428f8010a3d531165ae1&pi=6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:33Zoai:repositorio.ul.pt:10451/17749Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:31.070075Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
title Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
spellingShingle Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
Mesquita, Rui
title_short Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
title_full Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
title_fullStr Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
title_full_unstemmed Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
title_sort Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study
author Mesquita, Rui
author_facet Mesquita, Rui
Piçarra, Bruno
Saldanha, Carlota
Martins e Silva, J.
author_role author
author2 Piçarra, Bruno
Saldanha, Carlota
Martins e Silva, J.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mesquita, Rui
Piçarra, Bruno
Saldanha, Carlota
Martins e Silva, J.
description © 2002 – IOS Press. All rights reserved.
publishDate 2002
dc.date.none.fl_str_mv 2002
2002-01-01T00:00:00Z
2015-03-19T11:20:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/17749
url http://hdl.handle.net/10451/17749
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 27 (2002) 137–147
1386-0291
http://iospress.metapress.com/content/l2d3rg10j85yeqjq/?p=6f43ad018c42428f8010a3d531165ae1&pi=6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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