Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare”
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/72354 |
Resumo: | The already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, to generate drug-resistance and to diversify the populationlevel reservoir of M group viral subtypes. Compared to HIV-1 and other retroviruses, M. tuberculosis generates minute levels of genetic diversity within the host. However, emerging whole-genome sequencing data show that the M. tuberculosis complex contains at least nine human-adapted phylogenetic lineages. This level of genetic diversity results in differences in M. tuberculosis interactions with the host immune system, virulence and drug resistance propensity. In co-infected individuals, HIV-1 and M. tuberculosis are likely to co-colonize host cells. However, the evolutionary impact of the interaction between the host, the slowly evolving M. tuberculosis bacteria and the HIV-1 viral “mutant cloud” is poorly understood. These evolutionary dynamics, at the cellular niche of monocytes/macrophages, are also discussed and proposed as a relevant future research topic in the context of single-cell sequencing. |
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Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare”HIV-1Mycobacterium tuberculosisEvolutionary geneticsLineageSubtypeGenetic diversityTuberculosisAIDSMycobacteriumScience & TechnologyThe already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, to generate drug-resistance and to diversify the populationlevel reservoir of M group viral subtypes. Compared to HIV-1 and other retroviruses, M. tuberculosis generates minute levels of genetic diversity within the host. However, emerging whole-genome sequencing data show that the M. tuberculosis complex contains at least nine human-adapted phylogenetic lineages. This level of genetic diversity results in differences in M. tuberculosis interactions with the host immune system, virulence and drug resistance propensity. In co-infected individuals, HIV-1 and M. tuberculosis are likely to co-colonize host cells. However, the evolutionary impact of the interaction between the host, the slowly evolving M. tuberculosis bacteria and the HIV-1 viral “mutant cloud” is poorly understood. These evolutionary dynamics, at the cellular niche of monocytes/macrophages, are also discussed and proposed as a relevant future research topic in the context of single-cell sequencing.This work has been funded by National funds, through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020; by the projects NORTE-01- 0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Gilead Génese PGG/009/2017. ASP, CM, and PMMA were funded by FCT PhD scholarships PD/BD/127827/2016, SFRH/BD/132797/2017 and PDE/BDE/113599/2015, respectively.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoSantos-Pereira, AnaMagalhães, Carlos André RodriguesAraújo, Pedro M. M.Osório, Nuno S.20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72354engSantos-Pereira, A.; Magalhães, C.; Araújo, P.M.M.; Osório, N.S. Evolutionary Genetics of Mycobacterium Tuberculosis and HIV-1: “The Tortoise and the Hare”. Microorganisms 2021, 9, 147. https://doi.org/10.3390/microorganisms90101472076-260710.3390/microorganisms9010147https://www.mdpi.com/2076-2607/9/1/147info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:14:51Zoai:repositorium.sdum.uminho.pt:1822/72354Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:12.209911Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
title |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
spellingShingle |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” Santos-Pereira, Ana HIV-1 Mycobacterium tuberculosis Evolutionary genetics Lineage Subtype Genetic diversity Tuberculosis AIDS Mycobacterium Science & Technology |
title_short |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
title_full |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
title_fullStr |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
title_full_unstemmed |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
title_sort |
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
author |
Santos-Pereira, Ana |
author_facet |
Santos-Pereira, Ana Magalhães, Carlos André Rodrigues Araújo, Pedro M. M. Osório, Nuno S. |
author_role |
author |
author2 |
Magalhães, Carlos André Rodrigues Araújo, Pedro M. M. Osório, Nuno S. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Santos-Pereira, Ana Magalhães, Carlos André Rodrigues Araújo, Pedro M. M. Osório, Nuno S. |
dc.subject.por.fl_str_mv |
HIV-1 Mycobacterium tuberculosis Evolutionary genetics Lineage Subtype Genetic diversity Tuberculosis AIDS Mycobacterium Science & Technology |
topic |
HIV-1 Mycobacterium tuberculosis Evolutionary genetics Lineage Subtype Genetic diversity Tuberculosis AIDS Mycobacterium Science & Technology |
description |
The already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, to generate drug-resistance and to diversify the populationlevel reservoir of M group viral subtypes. Compared to HIV-1 and other retroviruses, M. tuberculosis generates minute levels of genetic diversity within the host. However, emerging whole-genome sequencing data show that the M. tuberculosis complex contains at least nine human-adapted phylogenetic lineages. This level of genetic diversity results in differences in M. tuberculosis interactions with the host immune system, virulence and drug resistance propensity. In co-infected individuals, HIV-1 and M. tuberculosis are likely to co-colonize host cells. However, the evolutionary impact of the interaction between the host, the slowly evolving M. tuberculosis bacteria and the HIV-1 viral “mutant cloud” is poorly understood. These evolutionary dynamics, at the cellular niche of monocytes/macrophages, are also discussed and proposed as a relevant future research topic in the context of single-cell sequencing. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/72354 |
url |
http://hdl.handle.net/1822/72354 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos-Pereira, A.; Magalhães, C.; Araújo, P.M.M.; Osório, N.S. Evolutionary Genetics of Mycobacterium Tuberculosis and HIV-1: “The Tortoise and the Hare”. Microorganisms 2021, 9, 147. https://doi.org/10.3390/microorganisms9010147 2076-2607 10.3390/microorganisms9010147 https://www.mdpi.com/2076-2607/9/1/147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132489985294336 |