Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid

Detalhes bibliográficos
Autor(a) principal: Le Sayec, Melanie
Data de Publicação: 2023
Outros Autores: Carregosa, Diogo, Khalifa, Khadija, de Lucia, Chiara, Aarsland, Dag, Santos, Cláudia N., Rodriguez-Mateos, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158438
Resumo: Funding Information: The authors thank Anthony Sullivan, Chris Titman, and Neil Loftus from Shimadzu UK Ltd for their support on the LC-MS/MS instrument. The authors also want to acknowledge and thank the participants for their kind effort during the study and all the research staff members at the three sites for their assistance and contribution to the conduction of the trial. Sources of support for the work : This work was funded by a grant from Nasjonalforeningen and Evonik Operations GmbH to D. A. and A. R. M. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement and European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement no. 804229, is acknowledged. Publisher Copyright: © 2023 The Royal Society of Chemistry.
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spelling Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluidevidence of their ability to cross the BBBFood ScienceFunding Information: The authors thank Anthony Sullivan, Chris Titman, and Neil Loftus from Shimadzu UK Ltd for their support on the LC-MS/MS instrument. The authors also want to acknowledge and thank the participants for their kind effort during the study and all the research staff members at the three sites for their assistance and contribution to the conduction of the trial. Sources of support for the work : This work was funded by a grant from Nasjonalforeningen and Evonik Operations GmbH to D. A. and A. R. M. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement and European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement no. 804229, is acknowledged. Publisher Copyright: © 2023 The Royal Society of Chemistry.Increasing evidence suggests that dietary (poly)phenols and methylxanthines have neuroprotective effects; however, little is known about whether they can cross the blood-brain barrier (BBB) and exert direct effects on the brain. We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid (CSF) from 90 individuals at risk of dementia using liquid chromatography-mass spectrometry and predicted their mechanism of transport across the BBB using in silico modelling techniques. A total of 123 and 127 metabolites were detected in CSF and plasma, respectively. In silico analysis suggests that 5 of the 20 metabolites quantified in CSF can cross the BBB by passive diffusion, while at least 9 metabolites require the aid of cell transporters to cross the BBB. Our results showed that (poly)phenols and methylxanthines are bioavailable, can cross the BBB via passive diffusion or transport carriers, and can reach brain tissues to exert neuroprotective effects.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNLe Sayec, MelanieCarregosa, DiogoKhalifa, Khadijade Lucia, ChiaraAarsland, DagSantos, Cláudia N.Rodriguez-Mateos, Ana2023-09-28T22:21:24Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158438eng2042-6496PURE: 72680963https://doi.org/10.1039/d3fo01913finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:50Zoai:run.unl.pt:10362/158438Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:08.478356Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
evidence of their ability to cross the BBB
title Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
spellingShingle Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
Le Sayec, Melanie
Food Science
title_short Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
title_full Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
title_fullStr Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
title_full_unstemmed Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
title_sort Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid
author Le Sayec, Melanie
author_facet Le Sayec, Melanie
Carregosa, Diogo
Khalifa, Khadija
de Lucia, Chiara
Aarsland, Dag
Santos, Cláudia N.
Rodriguez-Mateos, Ana
author_role author
author2 Carregosa, Diogo
Khalifa, Khadija
de Lucia, Chiara
Aarsland, Dag
Santos, Cláudia N.
Rodriguez-Mateos, Ana
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Le Sayec, Melanie
Carregosa, Diogo
Khalifa, Khadija
de Lucia, Chiara
Aarsland, Dag
Santos, Cláudia N.
Rodriguez-Mateos, Ana
dc.subject.por.fl_str_mv Food Science
topic Food Science
description Funding Information: The authors thank Anthony Sullivan, Chris Titman, and Neil Loftus from Shimadzu UK Ltd for their support on the LC-MS/MS instrument. The authors also want to acknowledge and thank the participants for their kind effort during the study and all the research staff members at the three sites for their assistance and contribution to the conduction of the trial. Sources of support for the work : This work was funded by a grant from Nasjonalforeningen and Evonik Operations GmbH to D. A. and A. R. M. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement and European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement no. 804229, is acknowledged. Publisher Copyright: © 2023 The Royal Society of Chemistry.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-28T22:21:24Z
2023-09
2023-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158438
url http://hdl.handle.net/10362/158438
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2042-6496
PURE: 72680963
https://doi.org/10.1039/d3fo01913f
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eu_rights_str_mv openAccess
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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