A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/842 |
Resumo: | The deposited article is a post-print version and has been submitted to peer review. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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A mechanism for the elimination of the female gamete centrosome in Drosophila melanogasterAnimalsCentriolesDrosophila ProteinsFemaleFertilizationGene DeletionMicrotubulesOocytesOvumProtein-Serine-Threonine KinasesDrosophila melanogasterOogenesisThe deposited article is a post-print version and has been submitted to peer review.This publication hasn't any creative commons license associated.This deposit is composed by the main article plus the supplementary materials of the publication.An important feature of fertilization is the asymmetric inheritance of centrioles. In most species it is the sperm that contributes the initial centriole, which builds the first centrosome that is essential for early development. However, given that centrioles are thought to be exceptionally stable structures, the mechanism behind centriole disappearance in the female germ line remains elusive and paradoxical. We elucidated a program for centriole maintenance in fruit flies, led by Polo kinase and the pericentriolar matrix (PCM): The PCM is down-regulated in the female germ line during oogenesis, which results in centriole loss. Perturbing this program prevents centriole loss, leading to abnormal meiotic and mitotic divisions, and thus to female sterility. This mechanism challenges the view that centrioles are intrinsically stable structures and reveals general functions for Polo kinase and the PCM in centriole maintenance. We propose that regulation of this maintenance program is essential for successful sexual reproduction and defines centriole life span in different tissues in homeostasis and disease, thereby shaping the cytoskeleton.Fundação Para a Ciência e Tecnologia grants: (SFRH/BD/33565/2008, SFRH/BPD/79680/2011, SFRH/BPD/87479/2012, PTDC/SAU-BD/105616/2008); Ciencia2007; EMBO Installation grant; ERC grant: (ERC-2010-StG-261344).American Association for the Advancement of ScienceARCAPimenta-Marques, A.Bento, I.Lopes, C. A. M.Duarte, P.Jana, S. C.Bettencourt-Dias, M.2018-02-21T16:56:07Z2016-07-012016-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/842engA. Pimenta-Marques et al ., Science 353 , aaf4866 (2016). DOI: 10.1126/science.aaf48610.1126/science.aaf4866info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:15Zoai:arca.igc.gulbenkian.pt:10400.7/842Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:03.555142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| title |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| spellingShingle |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster Pimenta-Marques, A. Animals Centrioles Drosophila Proteins Female Fertilization Gene Deletion Microtubules Oocytes Ovum Protein-Serine-Threonine Kinases Drosophila melanogaster Oogenesis |
| title_short |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| title_full |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| title_fullStr |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| title_full_unstemmed |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| title_sort |
A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster |
| author |
Pimenta-Marques, A. |
| author_facet |
Pimenta-Marques, A. Bento, I. Lopes, C. A. M. Duarte, P. Jana, S. C. Bettencourt-Dias, M. |
| author_role |
author |
| author2 |
Bento, I. Lopes, C. A. M. Duarte, P. Jana, S. C. Bettencourt-Dias, M. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Pimenta-Marques, A. Bento, I. Lopes, C. A. M. Duarte, P. Jana, S. C. Bettencourt-Dias, M. |
| dc.subject.por.fl_str_mv |
Animals Centrioles Drosophila Proteins Female Fertilization Gene Deletion Microtubules Oocytes Ovum Protein-Serine-Threonine Kinases Drosophila melanogaster Oogenesis |
| topic |
Animals Centrioles Drosophila Proteins Female Fertilization Gene Deletion Microtubules Oocytes Ovum Protein-Serine-Threonine Kinases Drosophila melanogaster Oogenesis |
| description |
The deposited article is a post-print version and has been submitted to peer review. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-07-01 2016-07-01T00:00:00Z 2018-02-21T16:56:07Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/842 |
| url |
http://hdl.handle.net/10400.7/842 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
A. Pimenta-Marques et al ., Science 353 , aaf4866 (2016). DOI: 10.1126/science.aaf486 10.1126/science.aaf4866 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
| publisher.none.fl_str_mv |
American Association for the Advancement of Science |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130575834972160 |