Hemorheological effects of sodium fluorescein in rats

Detalhes bibliográficos
Autor(a) principal: Sargento, L.
Data de Publicação: 1999
Outros Autores: Rosário, H. Sobral do, Saldanha, C., Martins e Silva, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/20174
Resumo: © 2001 – IOS Press. All rights reserved
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spelling Hemorheological effects of sodium fluorescein in rats© 2001 – IOS Press. All rights reservedSodium fluorescein is widely used in clinical practice for the study of the retinal circulation by angiography. It has been reported several hemorheological and microvascular abnormalities induced by this compound. The aim of this work was to analyse the hemorheological effects of intravenous sodium fluorescein in an animal model. Twenty male 10–16 weeks-old Wistar rats were used, under systemic anaesthesia. The animals were divided in 2 groups of 10 each: (1) intravenous injection of sodium fluorescein (14 mg/kg of body weight) – Group NaF, (2) controls (injection of NaCl 0.9%) – Group CTRL. A blood sample was drawn by aortic puncture after 60 minutes and hemorheological parameters determined: hematocrit, hemoglobin, metahemoglobin, carboxyhemoglobin, plasma viscosity, erythrocyte deformability, membrane fluidity and acetylcholinesterase activity. In the Group NaF there was a 20% reduction of the AChE activity (p < 0.05) and an increase in PV (p < 0.05). Concerning hemoglobin status, a three-fold increase in COHb (p < 0.001) was shown. In conclusion, the NaF injection in the animal model produces hemorheological abnormalities similar to those reported in the human.IOS PressRepositório da Universidade de LisboaSargento, L.Rosário, H. Sobral doSaldanha, C.Martins e Silva, J.2015-09-30T14:21:55Z19991999-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/20174engClinical Hemorheology and Microcirculation 24 (2001) 175–1811386-0291http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch441info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:05:23Zoai:repositorio.ul.pt:10451/20174Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:38:16.680379Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hemorheological effects of sodium fluorescein in rats
title Hemorheological effects of sodium fluorescein in rats
spellingShingle Hemorheological effects of sodium fluorescein in rats
Sargento, L.
title_short Hemorheological effects of sodium fluorescein in rats
title_full Hemorheological effects of sodium fluorescein in rats
title_fullStr Hemorheological effects of sodium fluorescein in rats
title_full_unstemmed Hemorheological effects of sodium fluorescein in rats
title_sort Hemorheological effects of sodium fluorescein in rats
author Sargento, L.
author_facet Sargento, L.
Rosário, H. Sobral do
Saldanha, C.
Martins e Silva, J.
author_role author
author2 Rosário, H. Sobral do
Saldanha, C.
Martins e Silva, J.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Sargento, L.
Rosário, H. Sobral do
Saldanha, C.
Martins e Silva, J.
description © 2001 – IOS Press. All rights reserved
publishDate 1999
dc.date.none.fl_str_mv 1999
1999-01-01T00:00:00Z
2015-09-30T14:21:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/20174
url http://hdl.handle.net/10451/20174
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 24 (2001) 175–181
1386-0291
http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch441
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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