Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity.
Autor(a) principal: | |
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Data de Publicação: | 1983 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 |
Resumo: | Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bactericidal activity on E. coil K 12 than cephaloridine and cefazolin. In presence of the latters in fact, bacterial regrowth was observed after 24 hours. On S. aureus a complete killing activity of cefotaxime appeared at concentrations of 8 x MIC. A synergism seemed to exist between the complement dependent bactericidal activity of normal human serum and cephalosporins. E. coil K 12 (a rough strain) was killed by the combination of human serum and both cefotaxime and cefazolin at concentrations that were not bactericidal by themselves. Cephaloridine on the contrary showed an additive activity with normal human serum. Finally evidence that cefotaxime enhanced the bactericidal activity of human polymorphonuclear leukocytes against S. faecaiis, is reported. |
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Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity.Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bactericidal activity on E. coil K 12 than cephaloridine and cefazolin. In presence of the latters in fact, bacterial regrowth was observed after 24 hours. On S. aureus a complete killing activity of cefotaxime appeared at concentrations of 8 x MIC. A synergism seemed to exist between the complement dependent bactericidal activity of normal human serum and cephalosporins. E. coil K 12 (a rough strain) was killed by the combination of human serum and both cefotaxime and cefazolin at concentrations that were not bactericidal by themselves. Cephaloridine on the contrary showed an additive activity with normal human serum. Finally evidence that cefotaxime enhanced the bactericidal activity of human polymorphonuclear leukocytes against S. faecaiis, is reported.Ordem dos Médicos1983-03-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790oai:ojs.www.actamedicaportuguesa.com:article/3790Acta Médica Portuguesa; Vol. 4 No. 3 (1983): Março; 167-171Acta Médica Portuguesa; Vol. 4 N.º 3 (1983): Março; 167-1711646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790/3048Gialdroni Grassi, GiulianaMangiarotti, PatriziaFietta, Annainfo:eu-repo/semantics/openAccess2022-12-20T11:02:47Zoai:ojs.www.actamedicaportuguesa.com:article/3790Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:33.143031Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
title |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
spellingShingle |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. Gialdroni Grassi, Giuliana |
title_short |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
title_full |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
title_fullStr |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
title_full_unstemmed |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
title_sort |
Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
author |
Gialdroni Grassi, Giuliana |
author_facet |
Gialdroni Grassi, Giuliana Mangiarotti, Patrizia Fietta, Anna |
author_role |
author |
author2 |
Mangiarotti, Patrizia Fietta, Anna |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gialdroni Grassi, Giuliana Mangiarotti, Patrizia Fietta, Anna |
description |
Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bactericidal activity on E. coil K 12 than cephaloridine and cefazolin. In presence of the latters in fact, bacterial regrowth was observed after 24 hours. On S. aureus a complete killing activity of cefotaxime appeared at concentrations of 8 x MIC. A synergism seemed to exist between the complement dependent bactericidal activity of normal human serum and cephalosporins. E. coil K 12 (a rough strain) was killed by the combination of human serum and both cefotaxime and cefazolin at concentrations that were not bactericidal by themselves. Cephaloridine on the contrary showed an additive activity with normal human serum. Finally evidence that cefotaxime enhanced the bactericidal activity of human polymorphonuclear leukocytes against S. faecaiis, is reported. |
publishDate |
1983 |
dc.date.none.fl_str_mv |
1983-03-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 oai:ojs.www.actamedicaportuguesa.com:article/3790 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3790 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790/3048 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 4 No. 3 (1983): Março; 167-171 Acta Médica Portuguesa; Vol. 4 N.º 3 (1983): Março; 167-171 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130637067616256 |