Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster

Detalhes bibliográficos
Autor(a) principal: Arif, Saad
Data de Publicação: 2013
Outros Autores: Murat, Sophie, Almudi, Isabel, Nunes, Maria D.S., Bortolamiol-Becet, Diane, McGregor, Naomi S., Currie, James M.S., Hughes, Harri, Ronshaugen, Matthew, Sucena, Élio, Lai, Eric C., Schlötterer, Christian, McGregor, Alistair P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/802
Resumo: The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials are present in the publisher's page in the following link: http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S0960982213001899/1-s2.0-S0960982213001899-mmc1.pdf/272099/html/S0960982213001899/187ecb1b8f94027ceebb87907c58eb3f/mmc1.pdf
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogasterAnimalsChromosome MappingDrosophila melanogasterExtremitiesFemaleIn Situ HybridizationMaleMicroRNAsPupaQuantitative Trait LociEvolution, MolecularGene Expression Regulation, DevelopmentalThe deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials are present in the publisher's page in the following link: http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S0960982213001899/1-s2.0-S0960982213001899-mmc1.pdf/272099/html/S0960982213001899/187ecb1b8f94027ceebb87907c58eb3f/mmc1.pdfIdentifying the genetic mechanisms underlying phenotypic change is essential to understanding how gene regulatory networks and ultimately the genotype-to-phenotype map evolve. It is recognized that microRNAs (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known examples of natural morphological variation caused by evolutionary changes in miRNA expression. Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4]. Drosophila melanogaster subgroup species display a portion of trichome-free cuticle on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. simulans [5, 6]. However, naked valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 μm(2). We investigated the genetic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbaby (svb) [7, 8] contributes to this morphological difference. Instead, we show that changes in mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9]. Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity.Austrian Science Fund (FWF) grant: (M1059-B09); Oxford Brookes University; National Institute of General Medical Sciences of the National Institutes of Health grant: (R01-GM083300).ElsevierARCAArif, SaadMurat, SophieAlmudi, IsabelNunes, Maria D.S.Bortolamiol-Becet, DianeMcGregor, Naomi S.Currie, James M.S.Hughes, HarriRonshaugen, MatthewSucena, ÉlioLai, Eric C.Schlötterer, ChristianMcGregor, Alistair P.2017-11-07T15:27:13Z2013-03-182013-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/802engSaad Arif, Sophie Murat, Isabel Almudi, Maria D.S. Nunes, Diane Bortolamiol-Becet, Naomi S. McGregor, James M.S. Currie, Harri Hughes, Matthew Ronshaugen, Élio Sucena, Eric C. Lai, Christian Schlötterer, Alistair P. McGregor, Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster, Current Biology, Volume 23, Issue 6, 18 March 2013, Pages 523-528, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2013.02.018. (https://www.sciencedirect.com/science/article/pii/S0960982213001899)10.1016/j.cub.2013.02.018info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:12Zoai:arca.igc.gulbenkian.pt:10400.7/802Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:01.606552Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
title Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
spellingShingle Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
Arif, Saad
Animals
Chromosome Mapping
Drosophila melanogaster
Extremities
Female
In Situ Hybridization
Male
MicroRNAs
Pupa
Quantitative Trait Loci
Evolution, Molecular
Gene Expression Regulation, Developmental
title_short Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
title_full Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
title_fullStr Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
title_full_unstemmed Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
title_sort Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster
author Arif, Saad
author_facet Arif, Saad
Murat, Sophie
Almudi, Isabel
Nunes, Maria D.S.
Bortolamiol-Becet, Diane
McGregor, Naomi S.
Currie, James M.S.
Hughes, Harri
Ronshaugen, Matthew
Sucena, Élio
Lai, Eric C.
Schlötterer, Christian
McGregor, Alistair P.
author_role author
author2 Murat, Sophie
Almudi, Isabel
Nunes, Maria D.S.
Bortolamiol-Becet, Diane
McGregor, Naomi S.
Currie, James M.S.
Hughes, Harri
Ronshaugen, Matthew
Sucena, Élio
Lai, Eric C.
Schlötterer, Christian
McGregor, Alistair P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Arif, Saad
Murat, Sophie
Almudi, Isabel
Nunes, Maria D.S.
Bortolamiol-Becet, Diane
McGregor, Naomi S.
Currie, James M.S.
Hughes, Harri
Ronshaugen, Matthew
Sucena, Élio
Lai, Eric C.
Schlötterer, Christian
McGregor, Alistair P.
dc.subject.por.fl_str_mv Animals
Chromosome Mapping
Drosophila melanogaster
Extremities
Female
In Situ Hybridization
Male
MicroRNAs
Pupa
Quantitative Trait Loci
Evolution, Molecular
Gene Expression Regulation, Developmental
topic Animals
Chromosome Mapping
Drosophila melanogaster
Extremities
Female
In Situ Hybridization
Male
MicroRNAs
Pupa
Quantitative Trait Loci
Evolution, Molecular
Gene Expression Regulation, Developmental
description The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials are present in the publisher's page in the following link: http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S0960982213001899/1-s2.0-S0960982213001899-mmc1.pdf/272099/html/S0960982213001899/187ecb1b8f94027ceebb87907c58eb3f/mmc1.pdf
publishDate 2013
dc.date.none.fl_str_mv 2013-03-18
2013-03-18T00:00:00Z
2017-11-07T15:27:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/802
url http://hdl.handle.net/10400.7/802
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Saad Arif, Sophie Murat, Isabel Almudi, Maria D.S. Nunes, Diane Bortolamiol-Becet, Naomi S. McGregor, James M.S. Currie, Harri Hughes, Matthew Ronshaugen, Élio Sucena, Eric C. Lai, Christian Schlötterer, Alistair P. McGregor, Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster, Current Biology, Volume 23, Issue 6, 18 March 2013, Pages 523-528, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2013.02.018. (https://www.sciencedirect.com/science/article/pii/S0960982213001899)
10.1016/j.cub.2013.02.018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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