Genetic basis of thermal plasticity variation in Drosophila melanogaster body size

Detalhes bibliográficos
Autor(a) principal: Lafuente, Elvira
Data de Publicação: 2018
Outros Autores: Duneau, David, Beldade, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/898
Resumo: This deposit is composed by the main article. The supplementary materials can be found on-line through the following link: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007686#sec017
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spelling Genetic basis of thermal plasticity variation in Drosophila melanogaster body sizeGenome-wide association studiesQuantitative trait lociAbdomenPhysiological parametersThoraxGenetic polymorphismMolecular geneticsDrosophila melanogasterThis deposit is composed by the main article. The supplementary materials can be found on-line through the following link: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007686#sec017Body size is a quantitative trait that is closely associated to fitness and under the control of both genetic and environmental factors. While developmental plasticity for this and other traits is heritable and under selection, little is known about the genetic basis for variation in plasticity that can provide the raw material for its evolution. We quantified genetic variation for body size plasticity in Drosophila melanogaster by measuring thorax and abdomen length of females reared at two temperatures from a panel representing naturally segregating alleles, the Drosophila Genetic Reference Panel (DGRP). We found variation between genotypes for the levels and direction of thermal plasticity in size of both body parts. We then used a Genome-Wide Association Study (GWAS) approach to unravel the genetic basis of inter-genotype variation in body size plasticity, and used different approaches to validate selected QTLs and to explore potential pleiotropic effects. We found mostly "private QTLs", with little overlap between the candidate loci underlying variation in plasticity for thorax versus abdomen size, for different properties of the plastic response, and for size versus size plasticity. We also found that the putative functions of plasticity QTLs were diverse and that alleles for higher plasticity were found at lower frequencies in the target population. Importantly, a number of our plasticity QTLs have been targets of selection in other populations. Our data sheds light onto the genetic basis of inter-genotype variation in size plasticity that is necessary for its evolution.Financial support for this work was provided by the Portuguese science funding agency, Fundação para a Ciência e Tecnologia, FCT: PhD fellowship to EL (SFRH/BD/52171/2013), and research grant to PB (PTDC/BIA-EVF/0017/2014); French research funding agency, Agence Nationale de la Recherche, ANR: Laboratory of Excellence TULIP, ANR-10-LABX-41 and ANR-11-IDEX-0002-02 (support for DD and PB) and French research centre, Centre National de la Recherche Scientifique, CNRS: International Associated Laboratory, LIA BEEG-B (support for DD and PB), and the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement (PCOFUND-GA-2013-609102), through the PRESTIGE programme coordinated by Campus France (support for DD). This work was developed with the support of the research infrastructure Congento, project LISBOA 01-0145-FEDER-022170, co-financed by Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Foundation for Science and Technology (FCT,Portugal). The funders had no role in study design,data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of ScienceARCALafuente, ElviraDuneau, DavidBeldade, Patrícia2018-10-10T11:50:16Z2018-09-262018-09-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/898engLafuente E, Duneau D, Beldade P (2018) Genetic basis of thermal plasticity variation in Drosophila melanogaster body size. PLoS Genet 14(9): e1007686. https://doi.org/10.1371/journal. pgen.100768610.1371/journal.pgen.1007686info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:18Zoai:arca.igc.gulbenkian.pt:10400.7/898Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:06.395366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
title Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
spellingShingle Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
Lafuente, Elvira
Genome-wide association studies
Quantitative trait loci
Abdomen
Physiological parameters
Thorax
Genetic polymorphism
Molecular genetics
Drosophila melanogaster
title_short Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
title_full Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
title_fullStr Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
title_full_unstemmed Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
title_sort Genetic basis of thermal plasticity variation in Drosophila melanogaster body size
author Lafuente, Elvira
author_facet Lafuente, Elvira
Duneau, David
Beldade, Patrícia
author_role author
author2 Duneau, David
Beldade, Patrícia
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Lafuente, Elvira
Duneau, David
Beldade, Patrícia
dc.subject.por.fl_str_mv Genome-wide association studies
Quantitative trait loci
Abdomen
Physiological parameters
Thorax
Genetic polymorphism
Molecular genetics
Drosophila melanogaster
topic Genome-wide association studies
Quantitative trait loci
Abdomen
Physiological parameters
Thorax
Genetic polymorphism
Molecular genetics
Drosophila melanogaster
description This deposit is composed by the main article. The supplementary materials can be found on-line through the following link: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007686#sec017
publishDate 2018
dc.date.none.fl_str_mv 2018-10-10T11:50:16Z
2018-09-26
2018-09-26T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/898
url http://hdl.handle.net/10400.7/898
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lafuente E, Duneau D, Beldade P (2018) Genetic basis of thermal plasticity variation in Drosophila melanogaster body size. PLoS Genet 14(9): e1007686. https://doi.org/10.1371/journal. pgen.1007686
10.1371/journal.pgen.1007686
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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