Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Detalhes bibliográficos
Autor(a) principal: Moreira, Vânia M. A.
Data de Publicação: 2007
Outros Autores: Vasaitis, Tadas S., Njar, Vincent C. O., Salvador, Jorge A. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
Resumo: A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
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spelling Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitorsIndazoleCYP17Prostate cancerAndrogen receptorPC cell linesA series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.2007-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/2792http://hdl.handle.net/10316/2792https://doi.org/10.1016/j.steroids.2007.08.004engMOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.Moreira, Vânia M. A.Vasaitis, Tadas S.Njar, Vincent C. O.Salvador, Jorge A. R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-07-28T11:50:21Zoai:estudogeral.uc.pt:10316/2792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:23.959137Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
spellingShingle Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Moreira, Vânia M. A.
Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
title_short Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_full Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_fullStr Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_full_unstemmed Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_sort Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
author Moreira, Vânia M. A.
author_facet Moreira, Vânia M. A.
Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
author_role author
author2 Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
author2_role author
author
author
dc.contributor.author.fl_str_mv Moreira, Vânia M. A.
Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
dc.subject.por.fl_str_mv Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
topic Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
description A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/2792
http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
url http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv MOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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