Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Detalhes bibliográficos
Autor(a) principal: Moreira, Vânia M. A.
Data de Publicação: 2007
Outros Autores: Vasaitis, Tadas S., Njar, Vincent C. O., Salvador, Jorge A. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1016/j.steroids.2007.08.004
Texto Completo: http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
Resumo: A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
id RCAP_b4f4b3b66659ab29b7392e4d6c692b14
oai_identifier_str oai:estudogeral.uc.pt:10316/2792
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitorsIndazoleCYP17Prostate cancerAndrogen receptorPC cell linesA series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.2007-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/2792http://hdl.handle.net/10316/2792https://doi.org/10.1016/j.steroids.2007.08.004engMOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.Moreira, Vânia M. A.Vasaitis, Tadas S.Njar, Vincent C. O.Salvador, Jorge A. R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-07-28T11:50:21Zoai:estudogeral.uc.pt:10316/2792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:23.959137Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
spellingShingle Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Moreira, Vânia M. A.
Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
Moreira, Vânia M. A.
Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
title_short Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_full Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_fullStr Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_full_unstemmed Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
title_sort Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
author Moreira, Vânia M. A.
author_facet Moreira, Vânia M. A.
Moreira, Vânia M. A.
Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
author_role author
author2 Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
author2_role author
author
author
dc.contributor.author.fl_str_mv Moreira, Vânia M. A.
Vasaitis, Tadas S.
Njar, Vincent C. O.
Salvador, Jorge A. R.
dc.subject.por.fl_str_mv Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
topic Indazole
CYP17
Prostate cancer
Androgen receptor
PC cell lines
description A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/2792
http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
url http://hdl.handle.net/10316/2792
https://doi.org/10.1016/j.steroids.2007.08.004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv MOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1822183344069148673
dc.identifier.doi.none.fl_str_mv 10.1016/j.steroids.2007.08.004

Registros relacionados