A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles

Detalhes bibliográficos
Autor(a) principal: Zare Jeddi, Maryam
Data de Publicação: 2021
Outros Autores: Virgolino, Ana, Fantke, Peter, Hopf, Nancy B., Galea, Karen S., Remy, Sylvie, Viegas, Susana, Mustieles, Vicente, Fernandez, Mariana F., von Goetz, Natalie, Vicente, Joana Lobo, Slobodnik, Jaroslav, Rambaud, Loïc, Denys, Sébastien, St-Amand, Annie, Nakayama, Shoji F., Santonen, Tiina, Barouki, Robert, Pasanen-Kase, Robert, Mol, Hans G.J., Vermeire, Theo, Jones, Kate, Silva, Maria João, Louro, Henriqueta, van der Voet, Hilko, Duca, Radu-Corneliu, Verhagen, Hans, Canova, Cristina, van Klaveren, Jacob, Kolossa-Gehring, Marike, Bessems, Jos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7784
Resumo: Data generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.
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spelling A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principlesHuman BiomonitoringEnvironmental GenotoxicityRegulatory Risk AssessmentRegistryData GovernanceData Value ChainHarmonisationGenotoxicidade AmbientalData generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.Elsevier/ Urban and FischerRepositório Científico do Instituto Nacional de SaúdeZare Jeddi, MaryamVirgolino, AnaFantke, PeterHopf, Nancy B.Galea, Karen S.Remy, SylvieViegas, SusanaMustieles, VicenteFernandez, Mariana F.von Goetz, NatalieVicente, Joana LoboSlobodnik, JaroslavRambaud, LoïcDenys, SébastienSt-Amand, AnnieNakayama, Shoji F.Santonen, TiinaBarouki, RobertPasanen-Kase, RobertMol, Hans G.J.Vermeire, TheoJones, KateSilva, Maria JoãoLouro, Henriquetavan der Voet, HilkoDuca, Radu-CorneliuVerhagen, HansCanova, Cristinavan Klaveren, JacobKolossa-Gehring, MarikeBessems, Jos2021-10-18T11:55:10Z2021-09-252021-09-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7784engInt J Hyg Environ Health. 2021 Sep 25;238:113826. doi: 10.1016/j.ijheh.2021.113826. Online ahead of print.1438-463910.1016/j.ijheh.2021.113826info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:13Zoai:repositorio.insa.pt:10400.18/7784Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:27.531792Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
title A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
spellingShingle A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
Zare Jeddi, Maryam
Human Biomonitoring
Environmental Genotoxicity
Regulatory Risk Assessment
Registry
Data Governance
Data Value Chain
Harmonisation
Genotoxicidade Ambiental
title_short A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
title_full A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
title_fullStr A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
title_full_unstemmed A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
title_sort A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
author Zare Jeddi, Maryam
author_facet Zare Jeddi, Maryam
Virgolino, Ana
Fantke, Peter
Hopf, Nancy B.
Galea, Karen S.
Remy, Sylvie
Viegas, Susana
Mustieles, Vicente
Fernandez, Mariana F.
von Goetz, Natalie
Vicente, Joana Lobo
Slobodnik, Jaroslav
Rambaud, Loïc
Denys, Sébastien
St-Amand, Annie
Nakayama, Shoji F.
Santonen, Tiina
Barouki, Robert
Pasanen-Kase, Robert
Mol, Hans G.J.
Vermeire, Theo
Jones, Kate
Silva, Maria João
Louro, Henriqueta
van der Voet, Hilko
Duca, Radu-Corneliu
Verhagen, Hans
Canova, Cristina
van Klaveren, Jacob
Kolossa-Gehring, Marike
Bessems, Jos
author_role author
author2 Virgolino, Ana
Fantke, Peter
Hopf, Nancy B.
Galea, Karen S.
Remy, Sylvie
Viegas, Susana
Mustieles, Vicente
Fernandez, Mariana F.
von Goetz, Natalie
Vicente, Joana Lobo
Slobodnik, Jaroslav
Rambaud, Loïc
Denys, Sébastien
St-Amand, Annie
Nakayama, Shoji F.
Santonen, Tiina
Barouki, Robert
Pasanen-Kase, Robert
Mol, Hans G.J.
Vermeire, Theo
Jones, Kate
Silva, Maria João
Louro, Henriqueta
van der Voet, Hilko
Duca, Radu-Corneliu
Verhagen, Hans
Canova, Cristina
van Klaveren, Jacob
Kolossa-Gehring, Marike
Bessems, Jos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Zare Jeddi, Maryam
Virgolino, Ana
Fantke, Peter
Hopf, Nancy B.
Galea, Karen S.
Remy, Sylvie
Viegas, Susana
Mustieles, Vicente
Fernandez, Mariana F.
von Goetz, Natalie
Vicente, Joana Lobo
Slobodnik, Jaroslav
Rambaud, Loïc
Denys, Sébastien
St-Amand, Annie
Nakayama, Shoji F.
Santonen, Tiina
Barouki, Robert
Pasanen-Kase, Robert
Mol, Hans G.J.
Vermeire, Theo
Jones, Kate
Silva, Maria João
Louro, Henriqueta
van der Voet, Hilko
Duca, Radu-Corneliu
Verhagen, Hans
Canova, Cristina
van Klaveren, Jacob
Kolossa-Gehring, Marike
Bessems, Jos
dc.subject.por.fl_str_mv Human Biomonitoring
Environmental Genotoxicity
Regulatory Risk Assessment
Registry
Data Governance
Data Value Chain
Harmonisation
Genotoxicidade Ambiental
topic Human Biomonitoring
Environmental Genotoxicity
Regulatory Risk Assessment
Registry
Data Governance
Data Value Chain
Harmonisation
Genotoxicidade Ambiental
description Data generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-18T11:55:10Z
2021-09-25
2021-09-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7784
url http://hdl.handle.net/10400.18/7784
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Hyg Environ Health. 2021 Sep 25;238:113826. doi: 10.1016/j.ijheh.2021.113826. Online ahead of print.
1438-4639
10.1016/j.ijheh.2021.113826
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/ Urban and Fischer
publisher.none.fl_str_mv Elsevier/ Urban and Fischer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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