Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/124955 |
Resumo: | Funding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulationAdipose tissueHypoxiaInflammationInsulin resistanceMetabolic dysfunctionObstructive sleep apneaOxidative stressBiochemistryPhysiologyMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingFunding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMartins, Fátima O.Sacramento, Joana F.Olea, ElenaMelo, Bernardete F.Prieto-Lloret, JesusObeso, AnaRocher, AsuncionMatafome, PauloMonteiro, Emilia C.Conde, Silvia V.2021-09-22T02:13:30Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/124955eng2076-3921PURE: 33695859https://doi.org/10.3390/antiox10081233info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:08Zoai:run.unl.pt:10362/124955Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:36.500468Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| title |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| spellingShingle |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation Martins, Fátima O. Adipose tissue Hypoxia Inflammation Insulin resistance Metabolic dysfunction Obstructive sleep apnea Oxidative stress Biochemistry Physiology Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
| title_short |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| title_full |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| title_fullStr |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| title_full_unstemmed |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| title_sort |
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation |
| author |
Martins, Fátima O. |
| author_facet |
Martins, Fátima O. Sacramento, Joana F. Olea, Elena Melo, Bernardete F. Prieto-Lloret, Jesus Obeso, Ana Rocher, Asuncion Matafome, Paulo Monteiro, Emilia C. Conde, Silvia V. |
| author_role |
author |
| author2 |
Sacramento, Joana F. Olea, Elena Melo, Bernardete F. Prieto-Lloret, Jesus Obeso, Ana Rocher, Asuncion Matafome, Paulo Monteiro, Emilia C. Conde, Silvia V. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Martins, Fátima O. Sacramento, Joana F. Olea, Elena Melo, Bernardete F. Prieto-Lloret, Jesus Obeso, Ana Rocher, Asuncion Matafome, Paulo Monteiro, Emilia C. Conde, Silvia V. |
| dc.subject.por.fl_str_mv |
Adipose tissue Hypoxia Inflammation Insulin resistance Metabolic dysfunction Obstructive sleep apnea Oxidative stress Biochemistry Physiology Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
| topic |
Adipose tissue Hypoxia Inflammation Insulin resistance Metabolic dysfunction Obstructive sleep apnea Oxidative stress Biochemistry Physiology Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
| description |
Funding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-09-22T02:13:30Z 2021-08 2021-08-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/124955 |
| url |
http://hdl.handle.net/10362/124955 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2076-3921 PURE: 33695859 https://doi.org/10.3390/antiox10081233 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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