Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1177/1721727X16677604 |
Resumo: | This work was supported by Fundacao para a Ciencia e a Tecnologia-FCT (Project PEst-OE/AGR/U10276/2014). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in ratsadrenocorticotropic hormone (ACTH)corticosteroneetomidatehemorrhagic shockIL-10IL-6injurylungrattumor necrosis factor (TNF)-αImmunology and AllergyImmunologyThis work was supported by Fundacao para a Ciencia e a Tecnologia-FCT (Project PEst-OE/AGR/U10276/2014).Hemorrhagic shock (HS) induces a compensatory endocrine and cytokine response which aims to restore homeostasis. This response can be modulated by general anesthetics. To our knowledge, no studies have evaluated if etomidate modulates this response in experimental HS. After being premedicated with buprenorphine (0.05 mg/kg subcutaneously), male Wistar rats were anaesthetized with 5% isoflurane and divided into three groups: G1 (control, n = 16), G2 (n = 13), and G3 (n = 14). G2 and G3 were subjected to HS by collecting 30% of their blood volume and resuscitated 90 min later with the collected blood and normal saline, in a 1:3 ratio, respectively. G3 received etomidate (1 mg/kg IV) before HS. Blood gas analysis, adrenocorticotropic hormone (ACTH), corticosterone, and plasma levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10 and of TNF-α, IL-6, and IL-10 mRNA obtained through real-time polymerase chain reaction (RT-PCR) were measured at 0, 90, 150, and 240 min after HS induction. Compared with G2, etomidate-treated animals had significantly lower corticosterone, PO2, PO2/FiO2, base excess and HCO3, and higher TNF-α, IL-6, IL-10, and TNF-α mRNA levels (P <0.05). Etomidate-treated rats showed impaired adrenal and increased cytokine response to HS and evidence of worse tissue oxygenation and lung dysfunction. Based on these results, and until further studies are performed to confirm if these findings occur in clinical patients, we suggest that etomidate should be used cautiously in HS.UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e IndustrialDEMI - Departamento de Engenharia Mecânica e IndustrialRUNFélix, Nuno M.Goy-Thollot, IsabelleWalton, Ronald S.Gil, Solange A.Mateus, Luísa M.Matos, Ana S.Niza, Maria M. R. E.2018-05-10T22:21:56Z2016-12-012016-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttps://doi.org/10.1177/1721727X16677604eng1721-727XPURE: 3830873http://www.scopus.com/inward/record.url?scp=85000384161&partnerID=8YFLogxKhttps://doi.org/10.1177/1721727X16677604info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:19:57Zoai:run.unl.pt:10362/36517Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:32.308167Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| title |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| spellingShingle |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats Félix, Nuno M. adrenocorticotropic hormone (ACTH) corticosterone etomidate hemorrhagic shock IL-10 IL-6 injury lung rat tumor necrosis factor (TNF)-α Immunology and Allergy Immunology |
| title_short |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| title_full |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| title_fullStr |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| title_full_unstemmed |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| title_sort |
Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats |
| author |
Félix, Nuno M. |
| author_facet |
Félix, Nuno M. Goy-Thollot, Isabelle Walton, Ronald S. Gil, Solange A. Mateus, Luísa M. Matos, Ana S. Niza, Maria M. R. E. |
| author_role |
author |
| author2 |
Goy-Thollot, Isabelle Walton, Ronald S. Gil, Solange A. Mateus, Luísa M. Matos, Ana S. Niza, Maria M. R. E. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial DEMI - Departamento de Engenharia Mecânica e Industrial RUN |
| dc.contributor.author.fl_str_mv |
Félix, Nuno M. Goy-Thollot, Isabelle Walton, Ronald S. Gil, Solange A. Mateus, Luísa M. Matos, Ana S. Niza, Maria M. R. E. |
| dc.subject.por.fl_str_mv |
adrenocorticotropic hormone (ACTH) corticosterone etomidate hemorrhagic shock IL-10 IL-6 injury lung rat tumor necrosis factor (TNF)-α Immunology and Allergy Immunology |
| topic |
adrenocorticotropic hormone (ACTH) corticosterone etomidate hemorrhagic shock IL-10 IL-6 injury lung rat tumor necrosis factor (TNF)-α Immunology and Allergy Immunology |
| description |
This work was supported by Fundacao para a Ciencia e a Tecnologia-FCT (Project PEst-OE/AGR/U10276/2014). |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-12-01 2016-12-01T00:00:00Z 2018-05-10T22:21:56Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1177/1721727X16677604 |
| url |
https://doi.org/10.1177/1721727X16677604 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1721-727X PURE: 3830873 http://www.scopus.com/inward/record.url?scp=85000384161&partnerID=8YFLogxK https://doi.org/10.1177/1721727X16677604 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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15 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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