Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29 |
Resumo: | Aims: The objectives of this study of bisphosphonate-related osteonecrosis of the jaws (BRONJ) were to determine local distribution, possible anatomically associated or determinant factors and other bone involvement of the disease, contributing with this new data towards the establishment of its prevalence in Portugal. Material and methods: The authors made a retrospective study of patients presenting BRONJ, at the Department of Stomatology of Santa Maria University Hospital, in Lisbon (42 cases) from 1st January 2004, to April 30rd, 2011. SPSS Statistics was implemented. Results: There was a higher prevalence of lesions in the lower jaw (66.7%), compared to the upper jaw (26.19%) and a significantly higher occurrence in alveolar bone (95.24%). The molars and premolars were the most affected areas (highest value at 6th sextant = 35.29%). In all cases, the onset of injury occurred after a medication period of up to 90 days, spontaneously in 14.29% of patients. Conclusions: For severity, BRONJ was a significant anatomoclinical entity in all 42 new cases in this study, and for discomfort (pain) in 81.1% of them. There was an anatomic correlation between the occurrence of the disease and its location in the jaws. There was a clinical association with trauma and type, route and length of administration of the bisphosphonate, with Zoledronate being adminis- tered intravenously in 76.19% of the cases. The jaws were the unique place where the disease occurred. Preventive measures should be implemented, avoiding trauma, and performing surgical procedures within 90 days after prescription. |
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Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective studyFactores Anatómicos Relacionados com a Osteonecrose dos Maxilares por Bisfosfonatos: Um Estudo Retrospectivo Realizado em PortugalAims: The objectives of this study of bisphosphonate-related osteonecrosis of the jaws (BRONJ) were to determine local distribution, possible anatomically associated or determinant factors and other bone involvement of the disease, contributing with this new data towards the establishment of its prevalence in Portugal. Material and methods: The authors made a retrospective study of patients presenting BRONJ, at the Department of Stomatology of Santa Maria University Hospital, in Lisbon (42 cases) from 1st January 2004, to April 30rd, 2011. SPSS Statistics was implemented. Results: There was a higher prevalence of lesions in the lower jaw (66.7%), compared to the upper jaw (26.19%) and a significantly higher occurrence in alveolar bone (95.24%). The molars and premolars were the most affected areas (highest value at 6th sextant = 35.29%). In all cases, the onset of injury occurred after a medication period of up to 90 days, spontaneously in 14.29% of patients. Conclusions: For severity, BRONJ was a significant anatomoclinical entity in all 42 new cases in this study, and for discomfort (pain) in 81.1% of them. There was an anatomic correlation between the occurrence of the disease and its location in the jaws. There was a clinical association with trauma and type, route and length of administration of the bisphosphonate, with Zoledronate being adminis- tered intravenously in 76.19% of the cases. The jaws were the unique place where the disease occurred. Preventive measures should be implemented, avoiding trauma, and performing surgical procedures within 90 days after prescription.Objectivos: São objectivos deste estudo sobre osteonecrose dos maxilares por bisfosfonatos (BRONJ), conhecer a distribuição local da doença, saber se existem factores anatómicos associados ou determinantes, se há outros ossos atingidos, e contribuir com novos dados para o estabelecimento da sua prevalência em Portugal. Materiais e métodos: Os autores fizeram um estudo retrospectivo dos doentes com osteonecrose dos maxilares por bisfosfonatos, do Serviço de Estomatologia do Hospital Universitário de Santa Maria em Lisboa (42 casos), de 1 de Janeiro de 2004 a 30 de Abril de 2011. Utilizaram o programa estatístico SPSS Vs.19. Resultados: Há uma maior prevalência de lesões na mandíbula (66,7%), quando comparada com a do maxilar superior (26,19%). É significativamente superior no osso alveolar (95,24%). A área de molares e pré-molares é a mais atingida (valor mais elevado no 6o sextante = 35,29%). Em todos os casos a lesão ocorreu após um período de medicação superior a noventa dias, espontaneamente em 14,29% dos doentes. Conclusões: A osteonecrose dos maxilares por bisfosfonatos é uma entidade anátomo-clínica relevante (42 novos casos neste es- tudo), pela gravidade e desconforto (dor em 81,1%). Existe correlação anatómica. Há associação ao trauma, tipo de bisfosfonato, via e tempo de administração. O Zoledronato foi administrado por via endovenosa em 76,19% dos doentes. Os maxilares foram o único local em que a doença ocorreu em todos os casos. Recomendam-se medidas preventivas, evitando o trauma e utilizando a janela de intervenção de 90 dias, após a prescrição.Ordem dos Médicos2012-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29oai:ojs.www.actamedicaportuguesa.com:article/29Acta Médica Portuguesa; Vol. 25 No. 2 (2012): March-April; 106-110Acta Médica Portuguesa; Vol. 25 N.º 2 (2012): Março-Abril; 106-1101646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29/35Álvares Furtado, IvoFranco Caldas, CecíliaLança, FernandaSalvado e Silva, Franciscoinfo:eu-repo/semantics/openAccess2022-12-20T10:55:43Zoai:ojs.www.actamedicaportuguesa.com:article/29Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:21.074653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study Factores Anatómicos Relacionados com a Osteonecrose dos Maxilares por Bisfosfonatos: Um Estudo Retrospectivo Realizado em Portugal |
title |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
spellingShingle |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study Álvares Furtado, Ivo |
title_short |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
title_full |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
title_fullStr |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
title_full_unstemmed |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
title_sort |
Anatomic Factors related to bisphosphonate Osteonecrosis of the Jaws: a Portuguese retrospective study |
author |
Álvares Furtado, Ivo |
author_facet |
Álvares Furtado, Ivo Franco Caldas, Cecília Lança, Fernanda Salvado e Silva, Francisco |
author_role |
author |
author2 |
Franco Caldas, Cecília Lança, Fernanda Salvado e Silva, Francisco |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Álvares Furtado, Ivo Franco Caldas, Cecília Lança, Fernanda Salvado e Silva, Francisco |
description |
Aims: The objectives of this study of bisphosphonate-related osteonecrosis of the jaws (BRONJ) were to determine local distribution, possible anatomically associated or determinant factors and other bone involvement of the disease, contributing with this new data towards the establishment of its prevalence in Portugal. Material and methods: The authors made a retrospective study of patients presenting BRONJ, at the Department of Stomatology of Santa Maria University Hospital, in Lisbon (42 cases) from 1st January 2004, to April 30rd, 2011. SPSS Statistics was implemented. Results: There was a higher prevalence of lesions in the lower jaw (66.7%), compared to the upper jaw (26.19%) and a significantly higher occurrence in alveolar bone (95.24%). The molars and premolars were the most affected areas (highest value at 6th sextant = 35.29%). In all cases, the onset of injury occurred after a medication period of up to 90 days, spontaneously in 14.29% of patients. Conclusions: For severity, BRONJ was a significant anatomoclinical entity in all 42 new cases in this study, and for discomfort (pain) in 81.1% of them. There was an anatomic correlation between the occurrence of the disease and its location in the jaws. There was a clinical association with trauma and type, route and length of administration of the bisphosphonate, with Zoledronate being adminis- tered intravenously in 76.19% of the cases. The jaws were the unique place where the disease occurred. Preventive measures should be implemented, avoiding trauma, and performing surgical procedures within 90 days after prescription. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-25 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29 oai:ojs.www.actamedicaportuguesa.com:article/29 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29 |
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oai:ojs.www.actamedicaportuguesa.com:article/29 |
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eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/29/35 |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 25 No. 2 (2012): March-April; 106-110 Acta Médica Portuguesa; Vol. 25 N.º 2 (2012): Março-Abril; 106-110 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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