Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children

Detalhes bibliográficos
Autor(a) principal: Laura, Aguiar
Data de Publicação: 2019
Outros Autores: Marinho, Cláudia, Martins, Rute, Alho, Irina, Ferreira, Joana, Quinhones Levy, Pilar, Faustino, Paula, Bicho, Manuel, Inácio, Ângela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6530
Resumo: Short Communication
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spelling Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese childrenGene InteractionGlutathioneHFEHaptoglobinInflammationObesityGenética HumanaObesidadeMetabolismo do FerroModificadores GenéticosDoenças GenéticasShort CommunicationObesity among children has emerged as a serious public health problem. The growing prevalence of childhood obesity has led to the appearance of serious complications, including a chronic systemic inflammation associated with oxidative stress. In the present study, we analysed the interaction between two genes related with iron metabolism - HFE and haptoglobin – and the plasmatic concentration of glutathione, as a way to evaluate the antioxidant response capacity in obesity. To achieve this, 118 obese children and 89 eutrophic children were recruited for the study. Results showed that although obese children present a significantly decreased tGSH levels, once we analysed separately children based on their haptoglobin phenotype, the decreased tGSH levels is significant only for the Hp 2 allele. Additionally, Hp 2.2 obese children carrying H63D polymorphism show significantly lower tGSH/GSSG values. Our results found an association of haptoglobin and HFE with oxidative stress in childhood obesity.The authors are grateful to all study participants and their families and would like to thank the Instituto de Investigação Científica Bento da Rocha Cabral for financial support.CMB Association PublisherRepositório Científico do Instituto Nacional de SaúdeLaura, AguiarMarinho, CláudiaMartins, RuteAlho, IrinaFerreira, JoanaQuinhones Levy, PilarFaustino, PaulaBicho, ManuelInácio, Ângela2020-04-27T08:17:05Z2019-02-282019-02-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6530engCell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-741165-158Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:34Zoai:repositorio.insa.pt:10400.18/6530Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:20.953918Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
spellingShingle Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
Laura, Aguiar
Gene Interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
Genética Humana
Obesidade
Metabolismo do Ferro
Modificadores Genéticos
Doenças Genéticas
title_short Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_full Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_fullStr Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_full_unstemmed Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_sort Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
author Laura, Aguiar
author_facet Laura, Aguiar
Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Quinhones Levy, Pilar
Faustino, Paula
Bicho, Manuel
Inácio, Ângela
author_role author
author2 Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Quinhones Levy, Pilar
Faustino, Paula
Bicho, Manuel
Inácio, Ângela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Laura, Aguiar
Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Quinhones Levy, Pilar
Faustino, Paula
Bicho, Manuel
Inácio, Ângela
dc.subject.por.fl_str_mv Gene Interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
Genética Humana
Obesidade
Metabolismo do Ferro
Modificadores Genéticos
Doenças Genéticas
topic Gene Interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
Genética Humana
Obesidade
Metabolismo do Ferro
Modificadores Genéticos
Doenças Genéticas
description Short Communication
publishDate 2019
dc.date.none.fl_str_mv 2019-02-28
2019-02-28T00:00:00Z
2020-04-27T08:17:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6530
url http://hdl.handle.net/10400.18/6530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-74
1165-158X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CMB Association Publisher
publisher.none.fl_str_mv CMB Association Publisher
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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