Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/901 |
Resumo: | Cilia are evolutionarily conserved structures with many sensory and motility-related functions. The ciliary base, composed of the basal body and the transition zone, is critical for cilia assembly and function, but its contribution to cilia diversity remains unknown. Hence, we generated a high-resolution structural and biochemical atlas of the ciliary base of four functionally distinct neuronal and sperm cilia types within an organism, Drosophila melanogaster. We uncovered a common scaffold and diverse structures associated with different localization of 15 evolutionarily conserved components. Furthermore, CEP290 (also known as NPHP6) is involved in the formation of highly diverse transition zone links. In addition, the cartwheel components SAS6 and ANA2 (also known as STIL) have an underappreciated role in basal body elongation, which depends on BLD10 (also known as CEP135). The differential expression of these cartwheel components contributes to diversity in basal body length. Our results offer a plausible explanation to how mutations in conserved ciliary base components lead to tissue-specific diseases. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Differential regulation of transition zone and centriole proteins contributes to ciliary base diversityAnimalsAnimals, Genetically ModifiedCaenorhabditis elegans ProteinsCell Cycle ProteinsCentriolesCiliaDrosophila ProteinsDrosophila melanogasterFemaleFertilityMaleMicrotubule-Associated ProteinsMutationNeuronsPhenotypeSignal TransductionSmellSpermatozoaTaxis ResponseCilia are evolutionarily conserved structures with many sensory and motility-related functions. The ciliary base, composed of the basal body and the transition zone, is critical for cilia assembly and function, but its contribution to cilia diversity remains unknown. Hence, we generated a high-resolution structural and biochemical atlas of the ciliary base of four functionally distinct neuronal and sperm cilia types within an organism, Drosophila melanogaster. We uncovered a common scaffold and diverse structures associated with different localization of 15 evolutionarily conserved components. Furthermore, CEP290 (also known as NPHP6) is involved in the formation of highly diverse transition zone links. In addition, the cartwheel components SAS6 and ANA2 (also known as STIL) have an underappreciated role in basal body elongation, which depends on BLD10 (also known as CEP135). The differential expression of these cartwheel components contributes to diversity in basal body length. Our results offer a plausible explanation to how mutations in conserved ciliary base components lead to tissue-specific diseases.ARCAJana, Swadhin ChandraMendonça, SusanaMachado, PedroWerner, SaschaRocha, JaquelinePereira, AntónioMaiato, HelderBettencourt-Dias, Mónica2019-07-25T13:56:48Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/901eng10.1038/s41556-018-0132-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:19Zoai:arca.igc.gulbenkian.pt:10400.7/901Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:06.566066Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
title |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
spellingShingle |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity Jana, Swadhin Chandra Animals Animals, Genetically Modified Caenorhabditis elegans Proteins Cell Cycle Proteins Centrioles Cilia Drosophila Proteins Drosophila melanogaster Female Fertility Male Microtubule-Associated Proteins Mutation Neurons Phenotype Signal Transduction Smell Spermatozoa Taxis Response |
title_short |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
title_full |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
title_fullStr |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
title_full_unstemmed |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
title_sort |
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
author |
Jana, Swadhin Chandra |
author_facet |
Jana, Swadhin Chandra Mendonça, Susana Machado, Pedro Werner, Sascha Rocha, Jaqueline Pereira, António Maiato, Helder Bettencourt-Dias, Mónica |
author_role |
author |
author2 |
Mendonça, Susana Machado, Pedro Werner, Sascha Rocha, Jaqueline Pereira, António Maiato, Helder Bettencourt-Dias, Mónica |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Jana, Swadhin Chandra Mendonça, Susana Machado, Pedro Werner, Sascha Rocha, Jaqueline Pereira, António Maiato, Helder Bettencourt-Dias, Mónica |
dc.subject.por.fl_str_mv |
Animals Animals, Genetically Modified Caenorhabditis elegans Proteins Cell Cycle Proteins Centrioles Cilia Drosophila Proteins Drosophila melanogaster Female Fertility Male Microtubule-Associated Proteins Mutation Neurons Phenotype Signal Transduction Smell Spermatozoa Taxis Response |
topic |
Animals Animals, Genetically Modified Caenorhabditis elegans Proteins Cell Cycle Proteins Centrioles Cilia Drosophila Proteins Drosophila melanogaster Female Fertility Male Microtubule-Associated Proteins Mutation Neurons Phenotype Signal Transduction Smell Spermatozoa Taxis Response |
description |
Cilia are evolutionarily conserved structures with many sensory and motility-related functions. The ciliary base, composed of the basal body and the transition zone, is critical for cilia assembly and function, but its contribution to cilia diversity remains unknown. Hence, we generated a high-resolution structural and biochemical atlas of the ciliary base of four functionally distinct neuronal and sperm cilia types within an organism, Drosophila melanogaster. We uncovered a common scaffold and diverse structures associated with different localization of 15 evolutionarily conserved components. Furthermore, CEP290 (also known as NPHP6) is involved in the formation of highly diverse transition zone links. In addition, the cartwheel components SAS6 and ANA2 (also known as STIL) have an underappreciated role in basal body elongation, which depends on BLD10 (also known as CEP135). The differential expression of these cartwheel components contributes to diversity in basal body length. Our results offer a plausible explanation to how mutations in conserved ciliary base components lead to tissue-specific diseases. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-07-25T13:56:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/901 |
url |
http://hdl.handle.net/10400.7/901 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1038/s41556-018-0132-1 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130576565829632 |