Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/24327 |
Resumo: | This paper describes the continuous-flow precipitation of hydroxyapatite Ca5(PO4)3OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37 °C. Precipitation of HAp was first carried out in a tubular microreactor immersed in an ultrasonic bath, where single-phase (laminar) flow and segmented gas-liquid flow were both evaluated. The single-phase flow study was then conducted in a novel microfluidic device developed at MIT. It consists of a Teflon stack microreactor with an integrated piezoelectric element (Teflon microreactor), thereby allowing the direct transmission of ultrasound to the reactor. Both microsystems produce single-phased calcium-deficient carbonated HAp under near-physiological conditions of temperature and pH. In addition, particle aggregation and primary particle size were significantly reduced in the segmented-flow tubular microreactor and in the Teflon microreactor. The as-prepared particles mostly consisted of rod-like shape nanoparticles with dimensions below 100 nm in length and around 20 nm in width. Further, the microreactors used yielded HAp particles with improved characteristics text was removed, namely higher crystallinity and less carbonate contamination, when compared to the HAp particles produced in a stirred tank batch reactor. |
id |
RCAP_c9728c37a0b2a395a9e4c26c3a09a8bf |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/24327 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystemsMicrofluidicsUltrasoundNanoparticlesHydroxyapatiteAggregationScience & TechnologyThis paper describes the continuous-flow precipitation of hydroxyapatite Ca5(PO4)3OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37 °C. Precipitation of HAp was first carried out in a tubular microreactor immersed in an ultrasonic bath, where single-phase (laminar) flow and segmented gas-liquid flow were both evaluated. The single-phase flow study was then conducted in a novel microfluidic device developed at MIT. It consists of a Teflon stack microreactor with an integrated piezoelectric element (Teflon microreactor), thereby allowing the direct transmission of ultrasound to the reactor. Both microsystems produce single-phased calcium-deficient carbonated HAp under near-physiological conditions of temperature and pH. In addition, particle aggregation and primary particle size were significantly reduced in the segmented-flow tubular microreactor and in the Teflon microreactor. The as-prepared particles mostly consisted of rod-like shape nanoparticles with dimensions below 100 nm in length and around 20 nm in width. Further, the microreactors used yielded HAp particles with improved characteristics text was removed, namely higher crystallinity and less carbonate contamination, when compared to the HAp particles produced in a stirred tank batch reactor.This work was supported by the Portuguese Foundation for Science and Technology (SFRH/BD/42992/2008) through the MIT-Portugal Program, Bioengineering Systems Focus Area. The authors are thankful to Dr. Speakman for his help with the X-ray measurements and with the interpretation of the results. S.K. acknowledges funding from the Swiss National Science Foundation (SNF).ElsevierElsevier BVUniversidade do MinhoCastro, FilipaKuhn, SimonJensen, KlavsFerreira, AntónioRocha, FernandoVicente, A. A.Teixeira, J. A.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24327eng1385-894710.1016/j.cej.2012.11.014info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:32Zoai:repositorium.sdum.uminho.pt:1822/24327Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:58.968373Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
title |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
spellingShingle |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems Castro, Filipa Microfluidics Ultrasound Nanoparticles Hydroxyapatite Aggregation Science & Technology |
title_short |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
title_full |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
title_fullStr |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
title_full_unstemmed |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
title_sort |
Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
author |
Castro, Filipa |
author_facet |
Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, A. A. Teixeira, J. A. |
author_role |
author |
author2 |
Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, A. A. Teixeira, J. A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, A. A. Teixeira, J. A. |
dc.subject.por.fl_str_mv |
Microfluidics Ultrasound Nanoparticles Hydroxyapatite Aggregation Science & Technology |
topic |
Microfluidics Ultrasound Nanoparticles Hydroxyapatite Aggregation Science & Technology |
description |
This paper describes the continuous-flow precipitation of hydroxyapatite Ca5(PO4)3OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37 °C. Precipitation of HAp was first carried out in a tubular microreactor immersed in an ultrasonic bath, where single-phase (laminar) flow and segmented gas-liquid flow were both evaluated. The single-phase flow study was then conducted in a novel microfluidic device developed at MIT. It consists of a Teflon stack microreactor with an integrated piezoelectric element (Teflon microreactor), thereby allowing the direct transmission of ultrasound to the reactor. Both microsystems produce single-phased calcium-deficient carbonated HAp under near-physiological conditions of temperature and pH. In addition, particle aggregation and primary particle size were significantly reduced in the segmented-flow tubular microreactor and in the Teflon microreactor. The as-prepared particles mostly consisted of rod-like shape nanoparticles with dimensions below 100 nm in length and around 20 nm in width. Further, the microreactors used yielded HAp particles with improved characteristics text was removed, namely higher crystallinity and less carbonate contamination, when compared to the HAp particles produced in a stirred tank batch reactor. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24327 |
url |
http://hdl.handle.net/1822/24327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1385-8947 10.1016/j.cej.2012.11.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Elsevier BV |
publisher.none.fl_str_mv |
Elsevier Elsevier BV |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132500761509888 |