Lípidos e imunidade

• Autor(a) principal: dos Santos Pereira de Moura, José Manuel
• Data de Publicação: 2003
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/1783
• topic: Inflamação; infecção; ácidos gordos polinsaturados (PUFA); eicosanóides; aterosclerose; Inflammation; infection; polyunsaturated fatty acids; eicosanoids; atherosclerosis

Epidemiologic data suggest a link betweenatherosclerosis and chronic infections and inflammatory conditions. During infection andinflammation, a wide range of alterations in metabolism occur. These are part of the body´s reaction known as the acute phase response (APR). Infection and inflammation can also perturb lipoprotein metabolism and produce a widevariety of changes in the plasma concentrations of lipids and lipoproteins.Eicosanoids are a group of oxygenated fattyacids with diverse and potent biological activity, produced from the fatty acids. The varietyof eicosanoids products and their correspondingly diverse physiological effects have been well characterized, and probably represent the best-understood relationship between lipids and biological function. Consequently, attempts tomodulate the production of eicosanoids musttarget either the enzyme activities responsible for synthesizing eicosanoids or the concentration of fatty acids substrate entering biological system through the diet.