Avoiding healthy cells extinction in a cancer model
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/5000 |
Resumo: | We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. For certain parameter choice, the dynamical system displays chaotic motion and by decreasing the response of the immune system to the tumor cells, a boundary crisis leading to transient chaotic dynamics is observed. This means that the system behaves chaotically for a finite amount of time until the unavoidable extinction of the healthy and immune cell populations occurs. Our main goal here is to apply a control method to avoid extinction. For that purpose, we apply the partial control method, which aims to control transient chaotic dynamics in the presence of external disturbances. As a result, we have succeeded to avoid the uncontrolled growth of tumor cells and the extinction of healthy tissue. The possibility of using this method compared to the frequently used therapies is discussed. (C) 2014 Elsevier Ltd. All rights reserved. |
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Avoiding healthy cells extinction in a cancer modelCancer ModelsPartial ControlChaosTumor GrowthTherapyWe consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. For certain parameter choice, the dynamical system displays chaotic motion and by decreasing the response of the immune system to the tumor cells, a boundary crisis leading to transient chaotic dynamics is observed. This means that the system behaves chaotically for a finite amount of time until the unavoidable extinction of the healthy and immune cell populations occurs. Our main goal here is to apply a control method to avoid extinction. For that purpose, we apply the partial control method, which aims to control transient chaotic dynamics in the presence of external disturbances. As a result, we have succeeded to avoid the uncontrolled growth of tumor cells and the extinction of healthy tissue. The possibility of using this method compared to the frequently used therapies is discussed. (C) 2014 Elsevier Ltd. All rights reserved.Academic Press LTD – Elsevier Science LTDRCIPLLopez, Álvaro G.Sabuco, JuanSeoane, Jesus M.Duarte, JorgeJanuário, CristinaSanjuan, Miguel A. F.2015-08-25T13:37:52Z2014-05-212014-05-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/5000engÁlvaro G.; [et al] – Avoiding healthy cells extinction in a cancer model. Journal of Theoretical Biology. ISSN: 0022-5193. Vol. 349 (2014), pp. 74-810022-519310.1016/j.jtbi.2014.01.040metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:47:49Zoai:repositorio.ipl.pt:10400.21/5000Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:20.943724Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Avoiding healthy cells extinction in a cancer model |
title |
Avoiding healthy cells extinction in a cancer model |
spellingShingle |
Avoiding healthy cells extinction in a cancer model Lopez, Álvaro G. Cancer Models Partial Control Chaos Tumor Growth Therapy |
title_short |
Avoiding healthy cells extinction in a cancer model |
title_full |
Avoiding healthy cells extinction in a cancer model |
title_fullStr |
Avoiding healthy cells extinction in a cancer model |
title_full_unstemmed |
Avoiding healthy cells extinction in a cancer model |
title_sort |
Avoiding healthy cells extinction in a cancer model |
author |
Lopez, Álvaro G. |
author_facet |
Lopez, Álvaro G. Sabuco, Juan Seoane, Jesus M. Duarte, Jorge Januário, Cristina Sanjuan, Miguel A. F. |
author_role |
author |
author2 |
Sabuco, Juan Seoane, Jesus M. Duarte, Jorge Januário, Cristina Sanjuan, Miguel A. F. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Lopez, Álvaro G. Sabuco, Juan Seoane, Jesus M. Duarte, Jorge Januário, Cristina Sanjuan, Miguel A. F. |
dc.subject.por.fl_str_mv |
Cancer Models Partial Control Chaos Tumor Growth Therapy |
topic |
Cancer Models Partial Control Chaos Tumor Growth Therapy |
description |
We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. For certain parameter choice, the dynamical system displays chaotic motion and by decreasing the response of the immune system to the tumor cells, a boundary crisis leading to transient chaotic dynamics is observed. This means that the system behaves chaotically for a finite amount of time until the unavoidable extinction of the healthy and immune cell populations occurs. Our main goal here is to apply a control method to avoid extinction. For that purpose, we apply the partial control method, which aims to control transient chaotic dynamics in the presence of external disturbances. As a result, we have succeeded to avoid the uncontrolled growth of tumor cells and the extinction of healthy tissue. The possibility of using this method compared to the frequently used therapies is discussed. (C) 2014 Elsevier Ltd. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-05-21 2014-05-21T00:00:00Z 2015-08-25T13:37:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/5000 |
url |
http://hdl.handle.net/10400.21/5000 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Álvaro G.; [et al] – Avoiding healthy cells extinction in a cancer model. Journal of Theoretical Biology. ISSN: 0022-5193. Vol. 349 (2014), pp. 74-81 0022-5193 10.1016/j.jtbi.2014.01.040 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press LTD – Elsevier Science LTD |
publisher.none.fl_str_mv |
Academic Press LTD – Elsevier Science LTD |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133401560645632 |