Stem cells as vehicles and targets of nanoparticles

Detalhes bibliográficos
Autor(a) principal: Pinho, Sónia
Data de Publicação: 2018
Outros Autores: Macedo, Maria H, Rebelo, Catarina Araujo Gomes, Sarmento, Bruno, Ferreira, Lino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/92397
https://doi.org/10.1016/j.drudis.2018.01.030
Resumo: Modulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells.
id RCAP_e9030a18296365352ca38a05d5beebdd
oai_identifier_str oai:estudogeral.uc.pt:10316/92397
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Stem cells as vehicles and targets of nanoparticlesAnimalsHumansNeoplasmsNanoparticlesStem CellsModulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells.This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the projects "Institute for Research 15 and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274 to BS); EC (ERC project nº 307384, “Nanotrigger” and ERA-Chair project nº 669088, ERA@UC, both to LF). SP, MHM and CR would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support (SFRH/BPD/96048/2013; SFRH/BD/131587/2017; SFRH/BD/52337/2013).Elsevier2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/92397http://hdl.handle.net/10316/92397https://doi.org/10.1016/j.drudis.2018.01.030eng13596446Pinho, SóniaMacedo, Maria HRebelo, Catarina Araujo GomesSarmento, BrunoFerreira, Linoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:08Zoai:estudogeral.uc.pt:10316/92397Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:30.248307Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stem cells as vehicles and targets of nanoparticles
title Stem cells as vehicles and targets of nanoparticles
spellingShingle Stem cells as vehicles and targets of nanoparticles
Pinho, Sónia
Animals
Humans
Neoplasms
Nanoparticles
Stem Cells
title_short Stem cells as vehicles and targets of nanoparticles
title_full Stem cells as vehicles and targets of nanoparticles
title_fullStr Stem cells as vehicles and targets of nanoparticles
title_full_unstemmed Stem cells as vehicles and targets of nanoparticles
title_sort Stem cells as vehicles and targets of nanoparticles
author Pinho, Sónia
author_facet Pinho, Sónia
Macedo, Maria H
Rebelo, Catarina Araujo Gomes
Sarmento, Bruno
Ferreira, Lino
author_role author
author2 Macedo, Maria H
Rebelo, Catarina Araujo Gomes
Sarmento, Bruno
Ferreira, Lino
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pinho, Sónia
Macedo, Maria H
Rebelo, Catarina Araujo Gomes
Sarmento, Bruno
Ferreira, Lino
dc.subject.por.fl_str_mv Animals
Humans
Neoplasms
Nanoparticles
Stem Cells
topic Animals
Humans
Neoplasms
Nanoparticles
Stem Cells
description Modulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/92397
http://hdl.handle.net/10316/92397
https://doi.org/10.1016/j.drudis.2018.01.030
url http://hdl.handle.net/10316/92397
https://doi.org/10.1016/j.drudis.2018.01.030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 13596446
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134012057321472

Registros relacionados