Biocompatible oligo-oxazoline crosslinkers

Detalhes bibliográficos
Autor(a) principal: Lopes, Mafalda
Data de Publicação: 2021
Outros Autores: Restani, Rita, Carvalho, Marco P., Correia, Ilídio, Aguiar-Ricardo, Ana, Bonifácio, Vasco D. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114331
Resumo: Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020).
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spelling Biocompatible oligo-oxazoline crosslinkersTowards advanced chitosans for controlled dug releaseChitosanCrosslinkingDexamethasoneOligo-oxazolinesSupercritical carbon dioxideChemistry(all)Environmental ChemistryBiochemistryChemical Engineering(all)Polymers and PlasticsMaterials ChemistryAssociate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020).Chitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers, based on oligo-oxazolines and glycidyl methacrylate copolymers, leading to patches with a very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by a controlled release administration. This study shows that oligo-oxazoline-crosslinked chitosan is a suitable biomaterial for loading and controlled release of dexamethasone.DQ - Departamento de QuímicaLAQV@REQUIMTERUNLopes, MafaldaRestani, RitaCarvalho, Marco P.Correia, IlídioAguiar-Ricardo, AnaBonifácio, Vasco D. B.2023-03-23T01:32:26Z2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/114331eng1381-5148PURE: 28433020https://doi.org/10.1016/j.reactfunctpolym.2021.104846info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:58Zoai:run.unl.pt:10362/114331Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:29.697754Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biocompatible oligo-oxazoline crosslinkers
Towards advanced chitosans for controlled dug release
title Biocompatible oligo-oxazoline crosslinkers
spellingShingle Biocompatible oligo-oxazoline crosslinkers
Lopes, Mafalda
Chitosan
Crosslinking
Dexamethasone
Oligo-oxazolines
Supercritical carbon dioxide
Chemistry(all)
Environmental Chemistry
Biochemistry
Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry
title_short Biocompatible oligo-oxazoline crosslinkers
title_full Biocompatible oligo-oxazoline crosslinkers
title_fullStr Biocompatible oligo-oxazoline crosslinkers
title_full_unstemmed Biocompatible oligo-oxazoline crosslinkers
title_sort Biocompatible oligo-oxazoline crosslinkers
author Lopes, Mafalda
author_facet Lopes, Mafalda
Restani, Rita
Carvalho, Marco P.
Correia, Ilídio
Aguiar-Ricardo, Ana
Bonifácio, Vasco D. B.
author_role author
author2 Restani, Rita
Carvalho, Marco P.
Correia, Ilídio
Aguiar-Ricardo, Ana
Bonifácio, Vasco D. B.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Lopes, Mafalda
Restani, Rita
Carvalho, Marco P.
Correia, Ilídio
Aguiar-Ricardo, Ana
Bonifácio, Vasco D. B.
dc.subject.por.fl_str_mv Chitosan
Crosslinking
Dexamethasone
Oligo-oxazolines
Supercritical carbon dioxide
Chemistry(all)
Environmental Chemistry
Biochemistry
Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry
topic Chitosan
Crosslinking
Dexamethasone
Oligo-oxazolines
Supercritical carbon dioxide
Chemistry(all)
Environmental Chemistry
Biochemistry
Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry
description Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020).
publishDate 2021
dc.date.none.fl_str_mv 2021-04
2021-04-01T00:00:00Z
2023-03-23T01:32:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114331
url http://hdl.handle.net/10362/114331
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1381-5148
PURE: 28433020
https://doi.org/10.1016/j.reactfunctpolym.2021.104846
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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