Freeform 3D printing using a continuous viscoelastic supporting matrix
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/28404 |
Resumo: | Embedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Freeform 3D printing using a continuous viscoelastic supporting matrixEmbedded 3D printingSupporting materialsContinuous matrixFreeform structuresHydrogelsEmbedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms.IOPscience2021-04-21T00:00:00Z2020-04-21T00:00:00Z2020-04-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28404eng17585082, 1758509010.1088/1758-5090/ab8bc3Patrício, Sónia GonçalvesSousa, Liliana R.Correia, Tiago RuivoGaspar, Vítor M.Pires, Liliana S.Luís, Jorge L.Oliveira, José MartinhoMano, Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:54:54Zoai:ria.ua.pt:10773/28404Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:56.346905Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
title |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
spellingShingle |
Freeform 3D printing using a continuous viscoelastic supporting matrix Patrício, Sónia Gonçalves Embedded 3D printing Supporting materials Continuous matrix Freeform structures Hydrogels |
title_short |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
title_full |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
title_fullStr |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
title_full_unstemmed |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
title_sort |
Freeform 3D printing using a continuous viscoelastic supporting matrix |
author |
Patrício, Sónia Gonçalves |
author_facet |
Patrício, Sónia Gonçalves Sousa, Liliana R. Correia, Tiago Ruivo Gaspar, Vítor M. Pires, Liliana S. Luís, Jorge L. Oliveira, José Martinho Mano, João |
author_role |
author |
author2 |
Sousa, Liliana R. Correia, Tiago Ruivo Gaspar, Vítor M. Pires, Liliana S. Luís, Jorge L. Oliveira, José Martinho Mano, João |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Patrício, Sónia Gonçalves Sousa, Liliana R. Correia, Tiago Ruivo Gaspar, Vítor M. Pires, Liliana S. Luís, Jorge L. Oliveira, José Martinho Mano, João |
dc.subject.por.fl_str_mv |
Embedded 3D printing Supporting materials Continuous matrix Freeform structures Hydrogels |
topic |
Embedded 3D printing Supporting materials Continuous matrix Freeform structures Hydrogels |
description |
Embedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-21T00:00:00Z 2020-04-21 2021-04-21T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/28404 |
url |
http://hdl.handle.net/10773/28404 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
17585082, 17585090 10.1088/1758-5090/ab8bc3 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IOPscience |
publisher.none.fl_str_mv |
IOPscience |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137665281425408 |