Freeform 3D printing using a continuous viscoelastic supporting matrix

Detalhes bibliográficos
Autor(a) principal: Patrício, Sónia Gonçalves
Data de Publicação: 2020
Outros Autores: Sousa, Liliana R., Correia, Tiago Ruivo, Gaspar, Vítor M., Pires, Liliana S., Luís, Jorge L., Oliveira, José Martinho, Mano, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/28404
Resumo: Embedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms.
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spelling Freeform 3D printing using a continuous viscoelastic supporting matrixEmbedded 3D printingSupporting materialsContinuous matrixFreeform structuresHydrogelsEmbedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms.IOPscience2021-04-21T00:00:00Z2020-04-21T00:00:00Z2020-04-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28404eng17585082, 1758509010.1088/1758-5090/ab8bc3Patrício, Sónia GonçalvesSousa, Liliana R.Correia, Tiago RuivoGaspar, Vítor M.Pires, Liliana S.Luís, Jorge L.Oliveira, José MartinhoMano, Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:54:54Zoai:ria.ua.pt:10773/28404Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:56.346905Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Freeform 3D printing using a continuous viscoelastic supporting matrix
title Freeform 3D printing using a continuous viscoelastic supporting matrix
spellingShingle Freeform 3D printing using a continuous viscoelastic supporting matrix
Patrício, Sónia Gonçalves
Embedded 3D printing
Supporting materials
Continuous matrix
Freeform structures
Hydrogels
title_short Freeform 3D printing using a continuous viscoelastic supporting matrix
title_full Freeform 3D printing using a continuous viscoelastic supporting matrix
title_fullStr Freeform 3D printing using a continuous viscoelastic supporting matrix
title_full_unstemmed Freeform 3D printing using a continuous viscoelastic supporting matrix
title_sort Freeform 3D printing using a continuous viscoelastic supporting matrix
author Patrício, Sónia Gonçalves
author_facet Patrício, Sónia Gonçalves
Sousa, Liliana R.
Correia, Tiago Ruivo
Gaspar, Vítor M.
Pires, Liliana S.
Luís, Jorge L.
Oliveira, José Martinho
Mano, João
author_role author
author2 Sousa, Liliana R.
Correia, Tiago Ruivo
Gaspar, Vítor M.
Pires, Liliana S.
Luís, Jorge L.
Oliveira, José Martinho
Mano, João
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Patrício, Sónia Gonçalves
Sousa, Liliana R.
Correia, Tiago Ruivo
Gaspar, Vítor M.
Pires, Liliana S.
Luís, Jorge L.
Oliveira, José Martinho
Mano, João
dc.subject.por.fl_str_mv Embedded 3D printing
Supporting materials
Continuous matrix
Freeform structures
Hydrogels
topic Embedded 3D printing
Supporting materials
Continuous matrix
Freeform structures
Hydrogels
description Embedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out of plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as in vitro models and organ-on-chip platforms.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-21T00:00:00Z
2020-04-21
2021-04-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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url http://hdl.handle.net/10773/28404
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 17585082, 17585090
10.1088/1758-5090/ab8bc3
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dc.publisher.none.fl_str_mv IOPscience
publisher.none.fl_str_mv IOPscience
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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