Determinants of HIV-1 late presentation in patients followed in europe
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/128853 |
Resumo: | Funding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Determinants of HIV-1 late presentation in patients followed in europeEuropeHIV-1 infectionLate presentationImmunology and AllergyMolecular BiologyImmunology and Microbiology(all)Microbiology (medical)Infectious DiseasesSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesMicrobiologia MédicaFunding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89,851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmis-sion, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)Population health, policies and services (PPS)RUNMiranda, Mafalda N.S.Pingarilho, MartaPimentel, VictorMartins, Maria Do Rosário O.Vandamme, Anne MiekeBobkova, MarinaBöhm, MichaelSeguin-Devaux, CaroleParedes, RogerRubio, RafaelZazzi, MaurizioIncardona, FrancescaAbecasis, Ana2021-12-07T23:42:28Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/128853eng2076-0817PURE: 33047814https://doi.org/10.3390/pathogens10070835info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:12Zoai:run.unl.pt:10362/128853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:24.839856Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Determinants of HIV-1 late presentation in patients followed in europe |
title |
Determinants of HIV-1 late presentation in patients followed in europe |
spellingShingle |
Determinants of HIV-1 late presentation in patients followed in europe Miranda, Mafalda N.S. Europe HIV-1 infection Late presentation Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities Microbiologia Médica |
title_short |
Determinants of HIV-1 late presentation in patients followed in europe |
title_full |
Determinants of HIV-1 late presentation in patients followed in europe |
title_fullStr |
Determinants of HIV-1 late presentation in patients followed in europe |
title_full_unstemmed |
Determinants of HIV-1 late presentation in patients followed in europe |
title_sort |
Determinants of HIV-1 late presentation in patients followed in europe |
author |
Miranda, Mafalda N.S. |
author_facet |
Miranda, Mafalda N.S. Pingarilho, Marta Pimentel, Victor Martins, Maria Do Rosário O. Vandamme, Anne Mieke Bobkova, Marina Böhm, Michael Seguin-Devaux, Carole Paredes, Roger Rubio, Rafael Zazzi, Maurizio Incardona, Francesca Abecasis, Ana |
author_role |
author |
author2 |
Pingarilho, Marta Pimentel, Victor Martins, Maria Do Rosário O. Vandamme, Anne Mieke Bobkova, Marina Böhm, Michael Seguin-Devaux, Carole Paredes, Roger Rubio, Rafael Zazzi, Maurizio Incardona, Francesca Abecasis, Ana |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) TB, HIV and opportunistic diseases and pathogens (THOP) Population health, policies and services (PPS) RUN |
dc.contributor.author.fl_str_mv |
Miranda, Mafalda N.S. Pingarilho, Marta Pimentel, Victor Martins, Maria Do Rosário O. Vandamme, Anne Mieke Bobkova, Marina Böhm, Michael Seguin-Devaux, Carole Paredes, Roger Rubio, Rafael Zazzi, Maurizio Incardona, Francesca Abecasis, Ana |
dc.subject.por.fl_str_mv |
Europe HIV-1 infection Late presentation Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities Microbiologia Médica |
topic |
Europe HIV-1 infection Late presentation Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities Microbiologia Médica |
description |
Funding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-07T23:42:28Z 2021-07 2021-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/128853 |
url |
http://hdl.handle.net/10362/128853 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-0817 PURE: 33047814 https://doi.org/10.3390/pathogens10070835 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138067755302912 |