American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure

Detalhes bibliográficos
Autor(a) principal: Marques,Sílvio Alencar
Data de Publicação: 2019
Outros Autores: Merlotto,Maira Renata, Ramos,Paulo Müller, Marques,Mariangela Esther Alencar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000300355
Resumo: Abstract: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
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spelling American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failureAmphotericin BKidney failure, chronicLeishmaniasisLeishmaniasis, cutaneousMegluminePancreatitisRenal insufficiency, chronicSkin ulcerAbstract: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.Sociedade Brasileira de Dermatologia2019-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000300355Anais Brasileiros de Dermatologia v.94 n.3 2019reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20198388info:eu-repo/semantics/openAccessMarques,Sílvio AlencarMerlotto,Maira RenataRamos,Paulo MüllerMarques,Mariangela Esther Alencareng2019-07-25T00:00:00Zoai:scielo:S0365-05962019000300355Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2019-07-25T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
spellingShingle American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
Marques,Sílvio Alencar
Amphotericin B
Kidney failure, chronic
Leishmaniasis
Leishmaniasis, cutaneous
Meglumine
Pancreatitis
Renal insufficiency, chronic
Skin ulcer
title_short American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_full American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_fullStr American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_full_unstemmed American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_sort American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
author Marques,Sílvio Alencar
author_facet Marques,Sílvio Alencar
Merlotto,Maira Renata
Ramos,Paulo Müller
Marques,Mariangela Esther Alencar
author_role author
author2 Merlotto,Maira Renata
Ramos,Paulo Müller
Marques,Mariangela Esther Alencar
author2_role author
author
author
dc.contributor.author.fl_str_mv Marques,Sílvio Alencar
Merlotto,Maira Renata
Ramos,Paulo Müller
Marques,Mariangela Esther Alencar
dc.subject.por.fl_str_mv Amphotericin B
Kidney failure, chronic
Leishmaniasis
Leishmaniasis, cutaneous
Meglumine
Pancreatitis
Renal insufficiency, chronic
Skin ulcer
topic Amphotericin B
Kidney failure, chronic
Leishmaniasis
Leishmaniasis, cutaneous
Meglumine
Pancreatitis
Renal insufficiency, chronic
Skin ulcer
description Abstract: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000300355
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000300355
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20198388
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.94 n.3 2019
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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