American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure

Detalhes bibliográficos
Autor(a) principal: Marques, Silvio Alencar [UNESP]
Data de Publicação: 2019
Outros Autores: Merlotto, Maira Renata [UNESP], Ramos, Paulo Muller [UNESP], Alencar Marques, Mariangela Esther [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20198388
http://hdl.handle.net/11449/185955
Resumo: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
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spelling American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failureAmphotericin BKidney failurechronicLeishmaniasiscutaneousMegluminePancreatitisRenal insufficiencySkin ulcerPentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.Univ Estadual Paulista, Fac Med Botucatu, Dept Dermatol & Radiotherapy, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Dermatol, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Pathol, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Dermatol & Radiotherapy, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Dermatol, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Pathol, Botucatu, SP, BrazilSoc Brasileira DermatologiaUniversidade Estadual Paulista (Unesp)Marques, Silvio Alencar [UNESP]Merlotto, Maira Renata [UNESP]Ramos, Paulo Muller [UNESP]Alencar Marques, Mariangela Esther [UNESP]2019-10-04T12:40:01Z2019-10-04T12:40:01Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article355-357application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20198388Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 94, n. 3, p. 355-357, 2019.0365-0596http://hdl.handle.net/11449/18595510.1590/abd1806-4841.20198388S0365-05962019000300355WOS:000477770000016S0365-05962019000300355.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros De Dermatologiainfo:eu-repo/semantics/openAccess2023-10-23T06:10:06Zoai:repositorio.unesp.br:11449/185955Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-23T06:10:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
spellingShingle American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
Marques, Silvio Alencar [UNESP]
Amphotericin B
Kidney failure
chronic
Leishmaniasis
cutaneous
Meglumine
Pancreatitis
Renal insufficiency
Skin ulcer
title_short American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_full American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_fullStr American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_full_unstemmed American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
title_sort American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
author Marques, Silvio Alencar [UNESP]
author_facet Marques, Silvio Alencar [UNESP]
Merlotto, Maira Renata [UNESP]
Ramos, Paulo Muller [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
author_role author
author2 Merlotto, Maira Renata [UNESP]
Ramos, Paulo Muller [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marques, Silvio Alencar [UNESP]
Merlotto, Maira Renata [UNESP]
Ramos, Paulo Muller [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
dc.subject.por.fl_str_mv Amphotericin B
Kidney failure
chronic
Leishmaniasis
cutaneous
Meglumine
Pancreatitis
Renal insufficiency
Skin ulcer
topic Amphotericin B
Kidney failure
chronic
Leishmaniasis
cutaneous
Meglumine
Pancreatitis
Renal insufficiency
Skin ulcer
description Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:40:01Z
2019-10-04T12:40:01Z
2019-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20198388
Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 94, n. 3, p. 355-357, 2019.
0365-0596
http://hdl.handle.net/11449/185955
10.1590/abd1806-4841.20198388
S0365-05962019000300355
WOS:000477770000016
S0365-05962019000300355.pdf
url http://dx.doi.org/10.1590/abd1806-4841.20198388
http://hdl.handle.net/11449/185955
identifier_str_mv Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 94, n. 3, p. 355-357, 2019.
0365-0596
10.1590/abd1806-4841.20198388
S0365-05962019000300355
WOS:000477770000016
S0365-05962019000300355.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros De Dermatologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 355-357
application/pdf
dc.publisher.none.fl_str_mv Soc Brasileira Dermatologia
publisher.none.fl_str_mv Soc Brasileira Dermatologia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1803046122847993856

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