Leprosy: a review of laboratory and therapeutic aspects - Part 2

Detalhes bibliográficos
Autor(a) principal: Lastória,Joel Carlos
Data de Publicação: 2014
Outros Autores: Abreu,Marilda Aparecida Milanez Morgado de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300389
Resumo: Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.
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spelling Leprosy: a review of laboratory and therapeutic aspects - Part 2Clinical evolutionCommunicable disease preventionDiagnosis, differentialDrug resistanceEducation, continuingLaboratory researchLeprosyMycobacterium lepraePrognosisTherapeuticsLeprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.Sociedade Brasileira de Dermatologia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300389Anais Brasileiros de Dermatologia v.89 n.3 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20142460info:eu-repo/semantics/openAccessLastória,Joel CarlosAbreu,Marilda Aparecida Milanez Morgado deeng2015-10-19T00:00:00Zoai:scielo:S0365-05962014000300389Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2015-10-19T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Leprosy: a review of laboratory and therapeutic aspects - Part 2
title Leprosy: a review of laboratory and therapeutic aspects - Part 2
spellingShingle Leprosy: a review of laboratory and therapeutic aspects - Part 2
Lastória,Joel Carlos
Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
title_short Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_full Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_fullStr Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_full_unstemmed Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_sort Leprosy: a review of laboratory and therapeutic aspects - Part 2
author Lastória,Joel Carlos
author_facet Lastória,Joel Carlos
Abreu,Marilda Aparecida Milanez Morgado de
author_role author
author2 Abreu,Marilda Aparecida Milanez Morgado de
author2_role author
dc.contributor.author.fl_str_mv Lastória,Joel Carlos
Abreu,Marilda Aparecida Milanez Morgado de
dc.subject.por.fl_str_mv Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
topic Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
description Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300389
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300389
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20142460
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.89 n.3 2014
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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