Leprosy: a review of laboratory and therapeutic aspects - Part 2

Detalhes bibliográficos
Autor(a) principal: Lastoria, Joel Carlos [UNESP]
Data de Publicação: 2014
Outros Autores: Abreu, Marilda Aparecida Milanez Morgado De
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20142460
http://hdl.handle.net/11449/109581
Resumo: Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.
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spelling Leprosy: a review of laboratory and therapeutic aspects - Part 2Clinical evolutionCommunicable disease preventionDiagnosis, differentialDrug resistanceEducation, continuingLaboratory researchLeprosyMycobacterium lepraePrognosisTherapeuticsLeprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de BotucatuUniversidade do Oeste Paulista Hospital Regional de Presidente PrudenteUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de BotucatuSociedade Brasileira de DermatologiaUniversidade Estadual Paulista (Unesp)Universidade do Oeste Paulista (UNOESTE)Lastoria, Joel Carlos [UNESP]Abreu, Marilda Aparecida Milanez Morgado De2014-09-30T18:18:29Z2014-09-30T18:18:29Z2014-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article389-401application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20142460Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 3, p. 389-401, 2014.0365-0596http://hdl.handle.net/11449/10958110.1590/abd1806-4841.20142460S0365-05962014000300389WOS:000337911100001S0365-05962014000300389.pdf9531498781164017SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0.8840,520info:eu-repo/semantics/openAccess2024-08-14T18:45:46Zoai:repositorio.unesp.br:11449/109581Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:45:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Leprosy: a review of laboratory and therapeutic aspects - Part 2
title Leprosy: a review of laboratory and therapeutic aspects - Part 2
spellingShingle Leprosy: a review of laboratory and therapeutic aspects - Part 2
Lastoria, Joel Carlos [UNESP]
Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
title_short Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_full Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_fullStr Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_full_unstemmed Leprosy: a review of laboratory and therapeutic aspects - Part 2
title_sort Leprosy: a review of laboratory and therapeutic aspects - Part 2
author Lastoria, Joel Carlos [UNESP]
author_facet Lastoria, Joel Carlos [UNESP]
Abreu, Marilda Aparecida Milanez Morgado De
author_role author
author2 Abreu, Marilda Aparecida Milanez Morgado De
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade do Oeste Paulista (UNOESTE)
dc.contributor.author.fl_str_mv Lastoria, Joel Carlos [UNESP]
Abreu, Marilda Aparecida Milanez Morgado De
dc.subject.por.fl_str_mv Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
topic Clinical evolution
Communicable disease prevention
Diagnosis, differential
Drug resistance
Education, continuing
Laboratory research
Leprosy
Mycobacterium leprae
Prognosis
Therapeutics
description Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-30T18:18:29Z
2014-09-30T18:18:29Z
2014-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20142460
Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 3, p. 389-401, 2014.
0365-0596
http://hdl.handle.net/11449/109581
10.1590/abd1806-4841.20142460
S0365-05962014000300389
WOS:000337911100001
S0365-05962014000300389.pdf
9531498781164017
url http://dx.doi.org/10.1590/abd1806-4841.20142460
http://hdl.handle.net/11449/109581
identifier_str_mv Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 3, p. 389-401, 2014.
0365-0596
10.1590/abd1806-4841.20142460
S0365-05962014000300389
WOS:000337911100001
S0365-05962014000300389.pdf
9531498781164017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0.884
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 389-401
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128157170008064

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