A high-fat diet as a model of fatty liver disease in rats

Detalhes bibliográficos
Autor(a) principal: Picchi,Monike Garlipp
Data de Publicação: 2011
Outros Autores: Mattos,Andresa Marques de, Barbosa,Marina Rodrigues, Duarte,Camila Passos, Gandini,Maria de Azevedo, Portari,Guilherme Vannucchi, Jordão,Alceu Afonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800006
Resumo: PURPOSE: The objective of the present study was to analyze the physiological and metabolic changes occurring in rats subjected to high-fat diet for one month. METHODS: The animals received a modified AIN-93 diet with increased lipid content and decreased carbohydrate content, while the control group received the normal AIN-93 diet. RESULTS: It was observed that the high-fat diet did not induce weight gain but led to greater gain of hepatic fat compared to control. Biochemcal parameters, glycemia, total cholesterol and serum protein did not differ between groups. In parallel, rats receiving the high-fat diet consumed less feed. CONCLUSION: The development of obesity through high-fat diet is associated with increased energy intake and time of exposure to the diet, while the metabolic syndrome is more associated with the combination of a diet rich in fat and carbohydrates.
id SBDPC-1_06d7c467c96df1d50bd4b6708666315f
oai_identifier_str oai:scielo:S0102-86502011000800006
network_acronym_str SBDPC-1
network_name_str Acta Cirúrgica Brasileira (Online)
repository_id_str
spelling A high-fat diet as a model of fatty liver disease in ratsObesityLipidsHyperphagiaWeight GainRatsPURPOSE: The objective of the present study was to analyze the physiological and metabolic changes occurring in rats subjected to high-fat diet for one month. METHODS: The animals received a modified AIN-93 diet with increased lipid content and decreased carbohydrate content, while the control group received the normal AIN-93 diet. RESULTS: It was observed that the high-fat diet did not induce weight gain but led to greater gain of hepatic fat compared to control. Biochemcal parameters, glycemia, total cholesterol and serum protein did not differ between groups. In parallel, rats receiving the high-fat diet consumed less feed. CONCLUSION: The development of obesity through high-fat diet is associated with increased energy intake and time of exposure to the diet, while the metabolic syndrome is more associated with the combination of a diet rich in fat and carbohydrates.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800006Acta Cirúrgica Brasileira v.26 suppl.2 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000800006info:eu-repo/semantics/openAccessPicchi,Monike GarlippMattos,Andresa Marques deBarbosa,Marina RodriguesDuarte,Camila PassosGandini,Maria de AzevedoPortari,Guilherme VannucchiJordão,Alceu Afonsoeng2011-10-24T00:00:00Zoai:scielo:S0102-86502011000800006Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-10-24T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv A high-fat diet as a model of fatty liver disease in rats
title A high-fat diet as a model of fatty liver disease in rats
spellingShingle A high-fat diet as a model of fatty liver disease in rats
Picchi,Monike Garlipp
Obesity
Lipids
Hyperphagia
Weight Gain
Rats
title_short A high-fat diet as a model of fatty liver disease in rats
title_full A high-fat diet as a model of fatty liver disease in rats
title_fullStr A high-fat diet as a model of fatty liver disease in rats
title_full_unstemmed A high-fat diet as a model of fatty liver disease in rats
title_sort A high-fat diet as a model of fatty liver disease in rats
author Picchi,Monike Garlipp
author_facet Picchi,Monike Garlipp
Mattos,Andresa Marques de
Barbosa,Marina Rodrigues
Duarte,Camila Passos
Gandini,Maria de Azevedo
Portari,Guilherme Vannucchi
Jordão,Alceu Afonso
author_role author
author2 Mattos,Andresa Marques de
Barbosa,Marina Rodrigues
Duarte,Camila Passos
Gandini,Maria de Azevedo
Portari,Guilherme Vannucchi
Jordão,Alceu Afonso
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Picchi,Monike Garlipp
Mattos,Andresa Marques de
Barbosa,Marina Rodrigues
Duarte,Camila Passos
Gandini,Maria de Azevedo
Portari,Guilherme Vannucchi
Jordão,Alceu Afonso
dc.subject.por.fl_str_mv Obesity
Lipids
Hyperphagia
Weight Gain
Rats
topic Obesity
Lipids
Hyperphagia
Weight Gain
Rats
description PURPOSE: The objective of the present study was to analyze the physiological and metabolic changes occurring in rats subjected to high-fat diet for one month. METHODS: The animals received a modified AIN-93 diet with increased lipid content and decreased carbohydrate content, while the control group received the normal AIN-93 diet. RESULTS: It was observed that the high-fat diet did not induce weight gain but led to greater gain of hepatic fat compared to control. Biochemcal parameters, glycemia, total cholesterol and serum protein did not differ between groups. In parallel, rats receiving the high-fat diet consumed less feed. CONCLUSION: The development of obesity through high-fat diet is associated with increased energy intake and time of exposure to the diet, while the metabolic syndrome is more associated with the combination of a diet rich in fat and carbohydrates.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000800006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 suppl.2 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
_version_ 1752126440816508928

Registros relacionados