The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

Detalhes bibliográficos
Autor(a) principal: Azevedo,Vera Lucia Fernandes de
Data de Publicação: 2013
Outros Autores: Santos,Paulo Sergio Santana, Oliveira Jr,Gildàsio Silveira de, Módolo,Gabriel Pinheiro, Domingues,Maria Aparecida Custódio, Castiglia,Yara Marcondes Machado, Vianna,Pedro Thadeu Galvão, Vane,Luiz Antonio, Módolo,Norma Sueli Pinheiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002
Resumo: PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
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spelling The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsAcute Kidney InjuryFluid TherapyColloidsHetastarchRatsPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002Acta Cirúrgica Brasileira v.28 n.1 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013000100002info:eu-repo/semantics/openAccessAzevedo,Vera Lucia Fernandes deSantos,Paulo Sergio SantanaOliveira Jr,Gildàsio Silveira deMódolo,Gabriel PinheiroDomingues,Maria Aparecida CustódioCastiglia,Yara Marcondes MachadoVianna,Pedro Thadeu GalvãoVane,Luiz AntonioMódolo,Norma Sueli Pinheiroeng2013-01-18T00:00:00Zoai:scielo:S0102-86502013000100002Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-01-18T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
spellingShingle The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Azevedo,Vera Lucia Fernandes de
Acute Kidney Injury
Fluid Therapy
Colloids
Hetastarch
Rats
title_short The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_full The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_fullStr The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_full_unstemmed The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_sort The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
author Azevedo,Vera Lucia Fernandes de
author_facet Azevedo,Vera Lucia Fernandes de
Santos,Paulo Sergio Santana
Oliveira Jr,Gildàsio Silveira de
Módolo,Gabriel Pinheiro
Domingues,Maria Aparecida Custódio
Castiglia,Yara Marcondes Machado
Vianna,Pedro Thadeu Galvão
Vane,Luiz Antonio
Módolo,Norma Sueli Pinheiro
author_role author
author2 Santos,Paulo Sergio Santana
Oliveira Jr,Gildàsio Silveira de
Módolo,Gabriel Pinheiro
Domingues,Maria Aparecida Custódio
Castiglia,Yara Marcondes Machado
Vianna,Pedro Thadeu Galvão
Vane,Luiz Antonio
Módolo,Norma Sueli Pinheiro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo,Vera Lucia Fernandes de
Santos,Paulo Sergio Santana
Oliveira Jr,Gildàsio Silveira de
Módolo,Gabriel Pinheiro
Domingues,Maria Aparecida Custódio
Castiglia,Yara Marcondes Machado
Vianna,Pedro Thadeu Galvão
Vane,Luiz Antonio
Módolo,Norma Sueli Pinheiro
dc.subject.por.fl_str_mv Acute Kidney Injury
Fluid Therapy
Colloids
Hetastarch
Rats
topic Acute Kidney Injury
Fluid Therapy
Colloids
Hetastarch
Rats
description PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502013000100002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.28 n.1 2013
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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