Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice

Detalhes bibliográficos
Autor(a) principal: Monteiro,Betânia Souza
Data de Publicação: 2012
Outros Autores: Del Carlo,Ricardo Junqueira, Argôlo-Neto,Napoleão Martins, Nardi,Nance Beyer, Carvalho,Pablo Herthel, Bonfá,Laila de Paula, Chagastelles,Pedro César, Moreira,Higo Nasser, Viloria,Marlene Isabel Vargas, Santos,Bianka Souza dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000300001
Resumo: PURPOSE: To evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp+ bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6. METHODS: The animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0µL of plasma gel containing 1.0 x 10(9) autologous platelets within the defect. RESULTS: In the treated group was observed process of angiogenesis and bone repair better than control group. CONCLUSION: Mesenchymal stem cells derived from bone marrow of C57BL/6 gfp+ mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.
id SBDPC-1_6a64d7cf17e5922d09586081b2bf7279
oai_identifier_str oai:scielo:S0102-86502012000300001
network_acronym_str SBDPC-1
network_name_str Acta Cirúrgica Brasileira (Online)
repository_id_str
spelling Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in miceMesenchymal Stem CellsPlatelet-Rich PlasmaTissue TherapySkullMicePURPOSE: To evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp+ bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6. METHODS: The animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0µL of plasma gel containing 1.0 x 10(9) autologous platelets within the defect. RESULTS: In the treated group was observed process of angiogenesis and bone repair better than control group. CONCLUSION: Mesenchymal stem cells derived from bone marrow of C57BL/6 gfp+ mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000300001Acta Cirúrgica Brasileira v.27 n.3 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000300001info:eu-repo/semantics/openAccessMonteiro,Betânia SouzaDel Carlo,Ricardo JunqueiraArgôlo-Neto,Napoleão MartinsNardi,Nance BeyerCarvalho,Pablo HerthelBonfá,Laila de PaulaChagastelles,Pedro CésarMoreira,Higo NasserViloria,Marlene Isabel VargasSantos,Bianka Souza doseng2012-03-27T00:00:00Zoai:scielo:S0102-86502012000300001Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-03-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
title Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
spellingShingle Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
Monteiro,Betânia Souza
Mesenchymal Stem Cells
Platelet-Rich Plasma
Tissue Therapy
Skull
Mice
title_short Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
title_full Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
title_fullStr Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
title_full_unstemmed Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
title_sort Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
author Monteiro,Betânia Souza
author_facet Monteiro,Betânia Souza
Del Carlo,Ricardo Junqueira
Argôlo-Neto,Napoleão Martins
Nardi,Nance Beyer
Carvalho,Pablo Herthel
Bonfá,Laila de Paula
Chagastelles,Pedro César
Moreira,Higo Nasser
Viloria,Marlene Isabel Vargas
Santos,Bianka Souza dos
author_role author
author2 Del Carlo,Ricardo Junqueira
Argôlo-Neto,Napoleão Martins
Nardi,Nance Beyer
Carvalho,Pablo Herthel
Bonfá,Laila de Paula
Chagastelles,Pedro César
Moreira,Higo Nasser
Viloria,Marlene Isabel Vargas
Santos,Bianka Souza dos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro,Betânia Souza
Del Carlo,Ricardo Junqueira
Argôlo-Neto,Napoleão Martins
Nardi,Nance Beyer
Carvalho,Pablo Herthel
Bonfá,Laila de Paula
Chagastelles,Pedro César
Moreira,Higo Nasser
Viloria,Marlene Isabel Vargas
Santos,Bianka Souza dos
dc.subject.por.fl_str_mv Mesenchymal Stem Cells
Platelet-Rich Plasma
Tissue Therapy
Skull
Mice
topic Mesenchymal Stem Cells
Platelet-Rich Plasma
Tissue Therapy
Skull
Mice
description PURPOSE: To evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp+ bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6. METHODS: The animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0µL of plasma gel containing 1.0 x 10(9) autologous platelets within the defect. RESULTS: In the treated group was observed process of angiogenesis and bone repair better than control group. CONCLUSION: Mesenchymal stem cells derived from bone marrow of C57BL/6 gfp+ mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000300001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000300001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012000300001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.3 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
_version_ 1752126440914026496

Registros relacionados