Natural products from marine red and brown algae against Trypanosoma cruzi
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600735 |
Resumo: | ABSTRACT Various extracts obtained from the red alga Plocamium brasiliense (Greville Howe & Taylor), including a fraction containing crude 5-chloro-1-(E)-chlorovinyl-2,4-dibromo-1,5-dimethylcyclohexane (1) and another containing a mixture of halogenated monoterpenes (F), as well as atomaric acid meroditerpene (2) isolated from brown alga Stypopodium zonale (J. V. Lamouroux) Papenfuss, were evaluated for their activity against Trypanosoma cruzi. The cytotoxic and trypanosomicidal effects of these extracts were evaluated in Vero cells and clinically relevant forms of T. cruzi (amastigotes and trypomastigotes). All extracts from P. brasiliense presented low cytotoxicity and moderate trypanosomicidal effects, except for the hydroalcoholic extract. The crude 1 and F fractions had enhanced trypanocidal activity but showed low selectivity. Moreover, atomaric acid (2) was identified as a hit, demonstrating a potent trypanocidal effect reaching an IC50 <10 µM against two different DTU (Yand high selectivity index (<10). These results identify marine natural products as promising candidates against Chagas disease. |
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Natural products from marine red and brown algae against Trypanosoma cruziSeaweed natural productsChagas diseaseTrypanosomicidal effects.ABSTRACT Various extracts obtained from the red alga Plocamium brasiliense (Greville Howe & Taylor), including a fraction containing crude 5-chloro-1-(E)-chlorovinyl-2,4-dibromo-1,5-dimethylcyclohexane (1) and another containing a mixture of halogenated monoterpenes (F), as well as atomaric acid meroditerpene (2) isolated from brown alga Stypopodium zonale (J. V. Lamouroux) Papenfuss, were evaluated for their activity against Trypanosoma cruzi. The cytotoxic and trypanosomicidal effects of these extracts were evaluated in Vero cells and clinically relevant forms of T. cruzi (amastigotes and trypomastigotes). All extracts from P. brasiliense presented low cytotoxicity and moderate trypanosomicidal effects, except for the hydroalcoholic extract. The crude 1 and F fractions had enhanced trypanocidal activity but showed low selectivity. Moreover, atomaric acid (2) was identified as a hit, demonstrating a potent trypanocidal effect reaching an IC50 <10 µM against two different DTU (Yand high selectivity index (<10). These results identify marine natural products as promising candidates against Chagas disease.Sociedade Brasileira de Farmacognosia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600735Revista Brasileira de Farmacognosia v.29 n.6 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2019.08.003info:eu-repo/semantics/openAccessTeixeira,Valéria LaneuvilleLima,Juliana Coelho RodriguesLechuga,Guilherme CurtyRamos,Carlos José BritoPereira,Mirian Claudia de SouzaCalvet,Claudia MagalhãesBourguignon,Saulo Cabraleng2020-01-30T00:00:00Zoai:scielo:S0102-695X2019000600735Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2020-01-30T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Natural products from marine red and brown algae against Trypanosoma cruzi |
title |
Natural products from marine red and brown algae against Trypanosoma cruzi |
spellingShingle |
Natural products from marine red and brown algae against Trypanosoma cruzi Teixeira,Valéria Laneuville Seaweed natural products Chagas disease Trypanosomicidal effects. |
title_short |
Natural products from marine red and brown algae against Trypanosoma cruzi |
title_full |
Natural products from marine red and brown algae against Trypanosoma cruzi |
title_fullStr |
Natural products from marine red and brown algae against Trypanosoma cruzi |
title_full_unstemmed |
Natural products from marine red and brown algae against Trypanosoma cruzi |
title_sort |
Natural products from marine red and brown algae against Trypanosoma cruzi |
author |
Teixeira,Valéria Laneuville |
author_facet |
Teixeira,Valéria Laneuville Lima,Juliana Coelho Rodrigues Lechuga,Guilherme Curty Ramos,Carlos José Brito Pereira,Mirian Claudia de Souza Calvet,Claudia Magalhães Bourguignon,Saulo Cabral |
author_role |
author |
author2 |
Lima,Juliana Coelho Rodrigues Lechuga,Guilherme Curty Ramos,Carlos José Brito Pereira,Mirian Claudia de Souza Calvet,Claudia Magalhães Bourguignon,Saulo Cabral |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira,Valéria Laneuville Lima,Juliana Coelho Rodrigues Lechuga,Guilherme Curty Ramos,Carlos José Brito Pereira,Mirian Claudia de Souza Calvet,Claudia Magalhães Bourguignon,Saulo Cabral |
dc.subject.por.fl_str_mv |
Seaweed natural products Chagas disease Trypanosomicidal effects. |
topic |
Seaweed natural products Chagas disease Trypanosomicidal effects. |
description |
ABSTRACT Various extracts obtained from the red alga Plocamium brasiliense (Greville Howe & Taylor), including a fraction containing crude 5-chloro-1-(E)-chlorovinyl-2,4-dibromo-1,5-dimethylcyclohexane (1) and another containing a mixture of halogenated monoterpenes (F), as well as atomaric acid meroditerpene (2) isolated from brown alga Stypopodium zonale (J. V. Lamouroux) Papenfuss, were evaluated for their activity against Trypanosoma cruzi. The cytotoxic and trypanosomicidal effects of these extracts were evaluated in Vero cells and clinically relevant forms of T. cruzi (amastigotes and trypomastigotes). All extracts from P. brasiliense presented low cytotoxicity and moderate trypanosomicidal effects, except for the hydroalcoholic extract. The crude 1 and F fractions had enhanced trypanocidal activity but showed low selectivity. Moreover, atomaric acid (2) was identified as a hit, demonstrating a potent trypanocidal effect reaching an IC50 <10 µM against two different DTU (Yand high selectivity index (<10). These results identify marine natural products as promising candidates against Chagas disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600735 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600735 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2019.08.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.29 n.6 2019 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122471338737664 |