Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata

Detalhes bibliográficos
Autor(a) principal: Prince,Karina Andrade de
Data de Publicação: 2012
Outros Autores: Sordi,Renata, Pavan,Fernando Rogério, Santos,Adolfo Carlos Barreto, Araujo,Angela R., Leite,Sergio R.A., Leite,Clarice Q. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100024
Resumo: Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
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spelling Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipataPhomopsis stipataantimycobacterial activityMycobacterium tuberculosisOur purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.Sociedade Brasileira de Microbiologia2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100024Brazilian Journal of Microbiology v.43 n.1 2012reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822012000100024info:eu-repo/semantics/openAccessPrince,Karina Andrade deSordi,RenataPavan,Fernando RogérioSantos,Adolfo Carlos BarretoAraujo,Angela R.Leite,Sergio R.A.Leite,Clarice Q. F.eng2012-05-02T00:00:00Zoai:scielo:S1517-83822012000100024Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2012-05-02T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
spellingShingle Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
Prince,Karina Andrade de
Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
title_short Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_full Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_fullStr Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_full_unstemmed Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_sort Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
author Prince,Karina Andrade de
author_facet Prince,Karina Andrade de
Sordi,Renata
Pavan,Fernando Rogério
Santos,Adolfo Carlos Barreto
Araujo,Angela R.
Leite,Sergio R.A.
Leite,Clarice Q. F.
author_role author
author2 Sordi,Renata
Pavan,Fernando Rogério
Santos,Adolfo Carlos Barreto
Araujo,Angela R.
Leite,Sergio R.A.
Leite,Clarice Q. F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Prince,Karina Andrade de
Sordi,Renata
Pavan,Fernando Rogério
Santos,Adolfo Carlos Barreto
Araujo,Angela R.
Leite,Sergio R.A.
Leite,Clarice Q. F.
dc.subject.por.fl_str_mv Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
topic Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
description Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822012000100024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.43 n.1 2012
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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